Current Concepts on the Clinical and Economic Impact of Periprosthetic Joint Infections
Orthop Clin North Am. 2024 Apr;55(2):151-159. doi: 10.1016/j.ocl.2023.09.001. Epub 2023 Oct 17.ABSTRACTTotal joint arthroplasty (TJA) is a common procedure performed throughout the entire world in hopes of alleviating debilitating hip or knee pain. The projected number of TJAs performed in the United States alone is projected to exceed 1.9 million by 2030 and 5 million by 2040. With the significant increase in TJA performed, more periprosthetic joint infections (PJIs) are likely to be encountered. PJIs are a devastating complication of TJA. The economic and clinical burden must be understood and respected to minimize occur...
Source: The Orthopedic Clinics of North America - February 25, 2024 Category: Orthopaedics Authors: Shaan Sadhwani Anthony Kamson Andrew J Frear Nadine Sadaka Kenneth L Urish Source Type: research

Biofilm and How It Relates to Prosthetic Joint Infection
Orthop Clin North Am. 2024 Apr;55(2):161-169. doi: 10.1016/j.ocl.2023.10.001. Epub 2023 Oct 29.ABSTRACTProsthetic joint infection following total joint arthroplasty is a devastating complication, resulting in increased morbidity and mortality for the patient. The formation of a biofilm on implanted hardware contributes to the difficulty in successful identification and eradication of the infection. Antibiotic therapy and surgical intervention are necessary for addressing this condition; we present a discussion on different treatment options, including those that are not yet routinely utilized in the clinical setting or are...
Source: The Orthopedic Clinics of North America - February 25, 2024 Category: Orthopaedics Authors: Ashley E MacConnell Ashley E Levack Nicholas M Brown Source Type: research

Innovations in the Isolation and Treatment of Biofilms in Periprosthetic Joint Infection: A Comprehensive Review of Current and Emerging Therapies in Bone and Joint Infection Management
This article focuses on the identification of biofilms, as well as current methodologies and emerging therapies in the management of biofilms in PJI.PMID:38403364 | DOI:10.1016/j.ocl.2023.10.002 (Source: The Orthopedic Clinics of North America)
Source: The Orthopedic Clinics of North America - February 25, 2024 Category: Orthopaedics Authors: Spencer A Ward Akram A Habibi Itay Ashkenazi Armin Arshi Morteza Meftah Ran Schwarzkopf Source Type: research

Articulating Spacers in Total Hip Arthroplasty: Surgical Technique and Outcomes
Orthop Clin North Am. 2024 Apr;55(2):181-192. doi: 10.1016/j.ocl.2023.06.002. Epub 2023 Aug 1.ABSTRACTAlthough one-stage exchange arthroplasty is gaining popularity, two-stage exchange arthroplasty remains the gold standard for the treatment of periprosthetic joint infections. Use of an articulating spacer for this procedure offers an avenue for maintaining hip motion and controlled weight-bearing, allowing local antibiotic elution. However, there is no uniform consensus on the optimal surgical protocol for using articulating spacers. This review describes the surgical technique for undertaking a first-stage exchange arthr...
Source: The Orthopedic Clinics of North America - February 25, 2024 Category: Orthopaedics Authors: Babar Kayani Francisco Bengoa Lisa C Howard Michael E Neufeld Bassam A Masri Source Type: research

Recurrent Periprosthetic Joint Infections: Diagnosis, Management, and Outcomes
Orthop Clin North Am. 2024 Apr;55(2):193-206. doi: 10.1016/j.ocl.2023.09.002. Epub 2023 Oct 10.ABSTRACTPeriprosthetic joint infection (PJI) remains one of the most common complications after total joint arthroplasty. It is challenging to manage, associated with significant morbidity and mortality, and is a financial burden on the health care system. Failure of 2-stage management for chronic PJI is not uncommon. Repeat infections are oftentimes polymicrobial, multiple drug-resistant microorganisms, or new organisms. Optimizing the success of index 2-stage revision is the greatest prevention against failure of any subsequent...
Source: The Orthopedic Clinics of North America - February 25, 2024 Category: Orthopaedics Authors: Christopher F Deans Beau J Kildow Kevin L Garvin Source Type: research