Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population
Conclusion: The current work reports the identification in the Japanese population of a BCRP polymorphism, not previously associated with the PK of any statin, that markedly increases ATA and o-OH-ATA exposure. The model developed may be of clinical importance to guide dosing recommendations tailored specifically for the Japanese. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - December 8, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
The influence of living donor SHROOM3 and ABCB1 genetic variants on renal function after kidney transplantation
Objective: A genome-wide association study has identified several gene polymorphisms associated with loss of renal function. The effect of these variants on renal function in kidney transplant recipients receiving immunosuppressive treatment is unknown.
Materials and methods: A cohort of 189 kidney transplant recipients and their living donors were recruited from West China Hospital of Sichuan University, on whom we assessed the association of five single nucleotide polymorphisms with renal function after kidney transplantation.
Results: Glomerular filtration rate estimated by serum creatinine was significantly higher in...
Source: Pharmacogenetics and Genomics - December 8, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Genome-wide association study of paliperidone efficacy
Objective: Clinical response to the atypical antipsychotic paliperidone is known to vary among schizophrenic patients. We carried out a genome-wide association study to identify common genetic variants predictive of paliperidone efficacy.
Methods: We leveraged a collection of 1390 samples from individuals of European ancestry enrolled in 12 clinical studies investigating the efficacy of the extended-release tablet paliperidone ER (n1=490) and the once-monthly injection paliperidone palmitate (n2=550 and n3=350). We carried out a genome-wide association study using a general linear model (GLM) analysis on three separate co...
Source: Pharmacogenetics and Genomics - December 8, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Concordance between actual and pharmacogenetic predicted desvenlafaxine dose needed to achieve remission in major depressive disorder: a 10-week open-label study
Conclusion: Findings provide initial evidence for the clinical validity of a polygene pharmacogenetic-based tool for desvenlafaxine dosing. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - December 8, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Thanks to the referees
No abstract available (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - November 1, 2016 Category: Genetics & Stem Cells Tags: Thanks to the Referees Source Type: research
PharmGKB summary: very important pharmacogene information for MT-RNR1
No abstract available (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - November 1, 2016 Category: Genetics & Stem Cells Tags: PharmGKB Summary Source Type: research
Prediction of early weight gain during psychotropic treatment using a combinatorial model with clinical and genetic markers
Background: Psychotropic drugs can induce significant (>5%) weight gain (WG) already after 1 month of treatment, which is a good predictor for major WG at 3 and 12 months. The large interindividual variability of drug-induced WG can be explained in part by genetic and clinical factors.
Aim: The aim of this study was to determine whether extensive analysis of genes, in addition to clinical factors, can improve prediction of patients at risk for more than 5% WG at 1 month of treatment.
Methods: Data were obtained from a 1-year naturalistic longitudinal study, with weight monitoring during weight-inducing psychotropic treat...
Source: Pharmacogenetics and Genomics - November 1, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
HLA-A*02 alleles are associated with tetanus antitoxin-induced exanthematous drug eruptions in Chinese patients
Conclusion: The HLA-A*02:06/-B*39:01 haplotype is a potential genetic marker for the TAT-induced EDE. Furthermore, the HLA-A2 serotype, especially three alleles A*02:01, A*02:06, and A*02:07, was identified to be associated with the TAT-induced EDE in the Han Chinese population for the first time. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - November 1, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Genetic variations associated with gemcitabine treatment outcome in pancreatic cancer
Background: Pancreatic cancer is a rapidly fatal disease with gemcitabine remaining the first-line therapy. We performed a genotype–phenotype association study to identify biomarkers for predicting gemcitabine treatment outcome.
Materials and methods: We selected the top 200 single nucleotide polymorphisms (SNPs) identified from our previous genome-wide association study to associate with overall survival using 400 patients treated with/or without gemcitabine, followed by imputation analysis for regions around the identified SNPs and a replication study using an additional 537 patients by the TaqMan genotyping assay. Fu...
Source: Pharmacogenetics and Genomics - November 1, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
MiR-pharmacogenetics of methotrexate in childhood B-cell acute lymphoblastic leukemia
Conclusion: In this study, we detected three SNPs in miR-5189, miR-595, and miR-6083 that might affect SLC46A1, SLC19A1, and SLCO1A2 MTX transport gene regulation and could affect MTX levels in patients with pediatric B-cell ALL. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - October 6, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Genetic determinants of variability in warfarin response after the dose-titration phase
Conclusion: The stability of anticoagulation after the warfarin dose-titration phase is differentially affected by variants in CYP4F2 in European-Americans and GGCX loci in African-Americans. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - October 6, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Impact of IL1B gene polymorphisms and interleukin 1B levels on susceptibility to spontaneous preterm birth
Conclusion: This study indicates a significant association between IL1B levels and reduced risk of PTB among the Malaysian Malay women. This study shows the impact of IL1B levels on susceptibility to PTB disease; however, the high levels of IL1B observed among women in the preterm group are not associated with IL1B SNPs investigated in this study; IL1B high levels may be because of other factors not explored in this study and therefore warrant further investigation. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - October 6, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
A novel block at chromosome 12q24.1 is associated with coronary artery disease in Han Chinese populations
Conclusion: We identified a novel block associated with CAD at chromosomal 12q24. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - October 6, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Pharmacogenetic study focused on fluoxetine pharmacodynamics in children and adolescent patients: impact of the serotonin pathway
Conclusion: Although a wide range of candidate genes related to different pathways were assessed, the results show that genetic markers directly related to serotonin have an important effect on fluoxetine response. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - October 6, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
β1-Adrenergic receptor Arg389Gly polymorphism affects the antiarrhythmic efficacy of flecainide in patients with coadministration of β-blockers
Conclusion: The Gly389 polymorphism decreased the antiarrhythmic efficacy of flecainide when coadministered with β-blockers. The results indicate that the Arg389Gly polymorphism may play an important role in predicting the efficacy of flecainide in patients with coadministration of β-blockers. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - September 9, 2016 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
