Indirubin Inhibits TRAIL-Induced Activation of Death Receptor 5 in Jurkat Cells
This study has elucidated previously unknown properties of indirubin that make it a promising candidate for therapeutic investigation of diseases in which overactivation of DR5 underlies pathology.PMID:37063699 | PMC:PMC10100512 | DOI:10.1177/1934578x221144580 (Source: Natural Product Communications)
Source: Natural Product Communications - April 17, 2023 Category: Biochemistry Authors: Malaney C Young Nagamani Vunnam Robyn T Rebbeck Samantha L Yuen David D Thomas Jonathan N Sachs Source Type: research
Phytochemical characterization and bioactivity toward breast cancer cells of unhydrolyzed and acid-hydrolyzed extracts of < em > Fagonia indica < /em >
In this study, we investigated the phytochemical composition of unhydrolyzed and acid-hydrolyzed extracts of Fagonia indica and their bioactivity toward breast cancer MCF-7 cells in vitro. The results revealed that F. indica contains phytochemicals consistent with the reported phytochemical composition of this Fagonia species, with greater amounts of aglycones detected in the hydrolyzed extract. The crude extract of F. indica without acid hydrolysis was found to be ineffective in inhibiting the growth of MCF-7 cells at doses below 1000 μg/mL. However, after acid hydrolysis (to mimic gastro-intestinal hydrolysis), the F. i...
Source: Natural Product Communications - July 25, 2022 Category: Biochemistry Authors: Cristobal L Miranda Yadano Kumbi Wenbin Wu Hyi-Seung Lee Ralph L Reed Jan F Stevens Source Type: research
