Symptomatic acute hypotension associated with high-dose dacarbazine
We observed several cases of hypotension associated with high-dose dacarbazine. We conducted a retrospective observational analysis of all patients treated with high-dose dacarbazine from January 2018 to August 2019 in Oscar Lambret Center, Lille, France. In our study, a total of 23 patients in outpatient care were analyzed, they underwent 57 treatment cycles. We observed 8 episodes of hypotension in 7 of the 23 consecutive treated patients (30.4%). We discuss herein several hypotheses explaining dacarbazine-induced hypotension. Dacarbazine high dose and administration methods seem to be the main causes of hypotension adve...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Short Communications: Clinical science Source Type: research
Conception and viable twin pregnancy in a patient with metastatic melanoma while treated with CTLA-4 and PD-1 checkpoint inhibition
In this report, we describe the successful pregnancy and clinical course of a patient diagnosed with metastatic melanoma who conceived twins while undergoing dual checkpoint blockade with ipilumumab and nivolumab. While there are case reports of patients receiving checkpoint inhibitors during pregnancy, our case is the first to describe a successful pregnancy that was conceived during treatment with combination anti-CTLA-4 and PD-1, with therapy continuing throughout pregnancy. This case adds to the growing evidence that favorable pregnancy outcomes may be possible while receiving checkpoint inhibition, which will hopefull...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Short Communications: Clinical science Source Type: research
Hibernoma as an incidental finding in the 18F-FDG PET/CT of a patient with melanoma
We present the case of a patient with cutaneous melanoma, diagnosed with a cervical hibernoma mimicking a metastatic lymph node at fluorine-18-fluorodeoxyglucose PET/CT. Being aware of the metabolic behavior and radiologic appearance of this entity may prevent reporting false-positive lesions, especially in an oncologic setting. (Source: Melanoma Research)
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Short Communications: Clinical science Source Type: research
Assessment of internet sources on subungual melanoma
In this study, we sought to objectively determine the accuracy and comprehensibility of online material with regard to subungual melanoma, a nail disease that is rare within the general population, yet has high incidence in certain patient groups, and carries a poorer prognosis than other forms of cutaneous melanoma. Because improved prognosis relies on early diagnosis, the dissemination of accurate, understandable information is an important factor in patient education and health. Using a pro forma designed to score website reliability, the accountability, quality, readability, display, support features, and transparency ...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Short Communications: Clinical science Source Type: research
Distinguishing melanophages from tumor in melanoma patients treated with talimogene laherparepvec
Response to talimogene laherparepvec (T-Vec) is difficult to assess as pigmented macrophages that have ingested melanoma cells (‘melanophages’) persist after injection, mimicking melanoma. We used quantitative immunofluorescence (qIF) to (1) distinguish melanophages from melanoma in biopsies from two patients treated with T-Vec and (2) evaluate the tumor microenvironment pretreatment and posttreatment. Tissues were stained with 4’,6-diamidino-2-phenylindole, cluster of differentiation (CD) 3, CD8, CD68, human leukocyte antigen-DR isotype (HLA-DR), and SRY-Box Transcription Factor 10 (SOX10), and multispectral images ...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Short Communications: Basic science Source Type: research
Incidence rate and risk factors for suicide death in patients with skin malignant melanoma: a Surveillance, Epidemiology, and End Results analysis
The purpose of this study was to use the Surveillance, Epidemiology, and End Results database to identify the incidence rate and risk factors for suicide death in patients with skin malignant melanoma (MM) in the USA. We screened cases of skin MM in the SEER database. The balance of covariates between the two groups was examined by the χ2-test and Fisher’s exact test. Logistic regression was used to identify independent risk factors for committing suicide. A propensity 1: 2 matched analysis was applied to minimize the risk of bias. In total, 103 500 patients with skin MM were included in the study, of whom 623 had died ...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Epidemiology Source Type: research
What has changed in the epidemiology of skin melanoma in central Italy during the past 20 years?
The aim was to evaluate changes in skin melanoma incidence and mortality at a population level in central Italy over the past two decades. Skin melanoma incidence rate from 1994 to 2014, were retrieved from the Umbrian Cancer Registry (about 900 000 inhabitants). Changes from 1994–1999 to 2010–2014 in tumour and patient characteristics – sex, age (0–44, 45–64, ≥ 65 years), site (head and neck, trunk, limbs), morphology (superficial spreading, nodular, other), thickness (≤ 1, 1–2, 2–4,> 4) and stage I–II, III–IV – were evaluated. Trends in age-standardized incidence and mortality rates were eva...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Epidemiology Source Type: research
Long-term relative survival from melanoma in Germany 1997–2013
This study aimed to provide recent 5-year and 10-year RS from melanoma, stratified by prognostic factors, and identify latest survival trends. Data from 12 German cancer registries were analysed. We included patients with primary cutaneous malignant melanoma (ICD-10: C43.X) diagnosed in 1997–2013 who were at least 15 years old. Five-year and 10-year RS were estimated by period analysis. For 10-year RS analyses, we excluded patients who were 75 years of age or older. Analyses were stratified by sex, age, histology, tumour stage, and body site. We included 82 901 patients, of whom 51% were women. The median age at diagnosi...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Epidemiology Source Type: research
Utilization and impact of immunotherapy in stage IV melanoma using the National Cancer Database
To evaluate factors affecting the utilization of immunotherapy and to stratify results based on the approval of ipilimumab in 2011 and PD-1 inhibitors in 2014, an analysis of available data from the National Cancer Database (NCDB) was performed. Stage IV melanoma patients were identified. Effects of immunotherapy on overall survival (OS) were assessed using Kaplan–Meier curves and Cox proportional hazards model. A total of 19 233 patients were analyzed and 1998 received immunotherapy. Between 2011 and 2013, and in 2014, 18.6 and 28.9% of patients received immunotherapy, respectively. Patients who received immunotherapy...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Epidemiology Source Type: research
Chemo-immunotherapy combination after PD-1 inhibitor failure improves clinical outcomes in metastatic melanoma patients
Management of PD-1 blockade resistance in metastatic melanoma (MM) remains challenging. Immunotherapy or chemotherapy alone provides limited benefit in this setting. Chemo-immunotherapy (CIT) has demonstrated favorable efficacy and safety profiles in lung cancer. Our pre-clinical study showed that in MM patients who have failed PD-1 blockade, the addition of chemotherapy increases CX3CR1+ therapy-responsive CD8+ T-cells with enhanced anti-tumor activity, resulting in improved clinical response. Here, we examined the clinical outcomes of CIT in MM patients after PD-1 blockade failure and the treatment-related changes in CX3...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Clinical research Source Type: research
Staging 18F-FDG PET/CT influences the treatment plan in melanoma patients with satellite or in-transit metastases
Whole-body positron emission tomography/computed tomography (PET/CT) and brain magnetic resonance imaging (MRI) are commonly used to stage patients with palpable lymph node metastases from melanoma, but their role in patients with satellite and/or in-transit metastasis (S&ITM) is unclear. The aim of this study was to establish the diagnostic value of PET/CT and brain MRI in these patients, and to assess their influence on subsequent management decisions. In this prospective study, 25 melanoma patients with a first presentation of S&ITM who had no clinical evidence of palpable nodal or distant metastasis underwent whole-bod...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Clinical research Source Type: research
The prognostic role of BRAF and WNT pathways activation in kinase inhibitors-naïve clinical stage III cutaneous melanoma
The results of local-regional advanced melanoma (stage III) management are still not satisfactory. Particularly, there is no personalized treatment in stage III melanoma patients due to the lack of useful classical pathological markers for prognostication of indolent or aggressive course of the disease. The aim of this study was to explore melanoma genomic landscape by means of the mutational profiling of 50 genes influencing carcinogenesis pathways in the randomly selected 93 kinase inhibitor-naïve (KI-naïve) stage III patients. The genomic alterations were found in 27 out of 50 tested genes and at least one pathogenic ...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Clinical research Source Type: research
Intracellular signaling modules linking DNA damage to secretome changes in senescent melanoma cells
Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanocyte and melanoma cell senescence is likely to come into play as a key factor affecting the course of tumorigenesis and responsiveness to therapy; little mechanistic information has been generated, however, that substantiates this idea and facilitates its clinical translation. Here, we established and character...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Basic science Source Type: research
Tacrolimus and ascomycin inhibit melanoma cell growth, migration and invasion via targeting nuclear factor of activated T-cell 3
Melanoma is the most malignant form of skin cancer with high metastatic potential. Nuclear factor of activated T-cells (NFATs) are discovered as transcription factors that regulate the expression of proinflammatory cytokines and other genes during the immune response. Among five NFAT members, NFAT3 is exclusively not expressed in immune cells and its role in progression of different types of cancer remains controversial. Our previous study showed that NFAT3 was highly expressed in skin cancer compared with normal skin tissues and critical for melanoma cell survival and tumor growth. Here, we reported that knockdown of NFAT...
Source: Melanoma Research - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Basic science Source Type: research
The successful use of pembrolizumab in a renal transplant recipient with metastatic melanoma
We report a case in which a renal transplant recipient with metastatic melanoma had an excellent response to treatment with second line programmed cell death protein 1 (PD-1) inhibitor therapy, pembrolizumab. Acute cellular allograft rejection on initiation of PD-1 inhibitor was successfully reversed with methylprednisolone. By converting the patient to sirolimus and giving predose prednisolone, pembrolizumab was continued with stable renal function and an excellent oncological response. This case supports the efficacy of PD-1 inhibitors in patients who are chronically immunosuppressed, and suggests an approach to maintain...
Source: Melanoma Research - May 2, 2020 Category: Cancer & Oncology Tags: Short Communications Source Type: research
