Simplified/Same Day(s)-GOLF as First-line Treatment of Metastatic Carcinoma of Unknown Primary (CUP), Suggestive of Pancreatobiliary Tumors.
Authors: Saif MW, Wasif K, Goodman MD, Hegde S, Sterling M, Yacavone R, Jaiswal S, Weinstein B, Daly K, Relias V Abstract Background: Carcinoma of unknown primary represents a therapeutic challenge in oncological practice. Evidence lacks to support particular chemotherapy selection and empirical therapies are commonly extrapolated from data on patients where primary tumor site is known. Gemcitabine, Oxaliplatin, Leucovorin and 5-Fluorouracil was previously developed to treat pancreatic cancer. These agents have also demonstrated activities in other gastrointestinal malignancies. Considering promising anti-tumor eff...
Source: Journal of the Pancreas - February 29, 2020 Category: Gastroenterology Tags: JOP Source Type: research

Does Neoadjuvant Therapy Improve Outcome in Resectable PC? Gastrointestinal Cancers Symposium 2019.
Authors: Ghaly M, Saif MW PMID: 32104167 [PubMed] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - February 29, 2020 Category: Gastroenterology Tags: JOP Source Type: research

Pancreatic Enzyme Replacement Therapy: A Concise Review.
Authors: Brennan GT, Saif MW Abstract Pancreatic enzyme replacement therapy is safe and effective at treating pancreatic exocrine insufficiency. There are multiple causes of pancreatic exocrine insufficiency including chronic pancreatitis, cystic fibrosis and pancreatic cancer. Testing fecal elastase-1 level is useful for the diagnosis of pancreatic exocrine insufficiency. Starting doses of pancreatic enzyme replacement therapy should be at least 30-40,000 IU with each meal and 15-20,000 IU with snacks. pancreatic enzyme replacement therapy should be taken in divided doses throughout meals. Patients who do not resp...
Source: Journal of the Pancreas - November 20, 2019 Category: Gastroenterology Tags: JOP Source Type: research

An Appraisal of Current Guidelines for Managing Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasm.
Authors: Takakura K, Torisu Y, Kinoshita Y, Tomita Y, Nakano M, Oikawa T, Tsukinaga S, Sumiyama K, Eibl G, Saruta M Abstract Pancreatic intraductal papillary mucinous neoplasm was originally regarded as a benign mucinous cystic tumor but certainly has a marked malignant potential. With the array of high-resolution imaging modalities that are now available, more frequent incidental asymptomatic intraductal papillary mucinous neoplasm patients can be diagnosed. Until now, our clinicians have been managing intraductal papillary mucinous neoplasm patients by referring to the international consensus guidelines which hav...
Source: Journal of the Pancreas - January 16, 2019 Category: Gastroenterology Tags: JOP Source Type: research

Comparable Responses in Male and Female Mice to Cerulein-Induced Chronic Pancreatic Injury and Recovery.
Conclusions: Male and female mice of the cerulein-induced chronic pancreatitis demonstrate similar responses to chronic pancreatitis injury and recovery. Although this model may not sufficiently emulate sex-dependent responses in human chronic pancreatitis, our study supports that both sexes of mice from this model can be used for the study of chronic pancreatitis. PMID: 30636940 [PubMed] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - January 16, 2019 Category: Gastroenterology Tags: JOP Source Type: research

Cutaneous Metastasis of Gastroenteropancreatic Neuroendocrine Tumors (GEP-Nets).
Discussion: Gastroenteropancreatic neuroendocrine tumors often metastasize to lymph nodes and liver but rarely can involve the skin and present as firm papules as found in our patient. Cutaneous metastasis of gastroenteropancreatic neuroendocrine tumors often has high morbidity and mortality and is usually associated with a primary lesion in the bronchopulmonary system. However, as demonstrated in this case report, cutaneous metastasis can originate from the gastrointestinal tract, including the small intestine as well. PMID: 30405324 [PubMed] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - November 10, 2018 Category: Gastroenterology Tags: JOP Source Type: research

Pancrelipase-Induced Hypersensitivity Reaction: Case Report and Review of Literature.
Discussion: As pancrelipase is a commonly prescribed drug, clinicians should be aware of the potential hypersensitivity skin reactions associated with pancrelipase. PMID: 30405325 [PubMed] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - November 10, 2018 Category: Gastroenterology Tags: JOP Source Type: research

Screening of Pancreatic Cancer.
Authors: Saif MW PMID: 30057517 [PubMed] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - August 2, 2018 Category: Gastroenterology Tags: JOP Source Type: research

Perioperative and Survival Outcomes Following Neoadjuvant FOLFIRINOX versus Gemcitabine Abraxane in Patients with Pancreatic Adenocarcinoma.
Conclusion: Neoadjuvant FOLFIRINOX may improve progression free survival by increasing the proportion of patients undergoing surgical resection. Improved understanding of the role for selection bias and longer follow up are needed to better define the impact of neoadjuvant FOLFIRINOX on overall survival. PMID: 29950957 [PubMed] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - June 29, 2018 Category: Gastroenterology Tags: JOP Source Type: research

Preventing Post-ERCP Pancreatitis: The Role of Prophylactic Pancreatic Duct Stenting in the Rectal NSAID Era.
Conclusion: A lack of difference in post-ERCP pancreatitis in those who underwent successful, and unsuccessful, pancreatic duct stent placement may reflect the protective effect of non-steroidal anti-inflammatory drugs. This data adds to evidence suggesting that pancreatic duct stenting may be less important, even in high-risk patients, with the widespread use of non-steroidal anti-inflammatory drugs. PMID: 29731700 [PubMed] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - May 9, 2018 Category: Gastroenterology Tags: JOP Source Type: research

Management of Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs) in 2017.
Authors: Saif MW PMID: 29599665 [PubMed] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - March 31, 2018 Category: Gastroenterology Tags: JOP Source Type: research

Diabetes Type 2 and Pancreatic Cancer: A History Unfolding.
This article is intended to clarify the evidence about diabetes as a risk factor for pancreatic cancer. PMID: 29568247 [PubMed] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - March 26, 2018 Category: Gastroenterology Tags: JOP Source Type: research

The Burden of Systemic Adiposity on Pancreatic Disease: Acute Pancreatitis, Non-Alcoholic Fatty Pancreas Disease, and Pancreatic Cancer.
Authors: Malli A, Li F, Conwell DL, Cruz-Monserrate Z, Hussan H, Krishna SG Abstract Obesity is a global epidemic as recognized by the World Health Organization. Obesity and its related comorbid conditions were recognized to have an important role in a multitude of acute, chronic, and critical illnesses including acute pancreatitis, nonalcoholic fatty pancreas disease, and pancreatic cancer. This review summarizes the impact of adiposity on a spectrum of pancreatic diseases. PMID: 29491829 [PubMed - in process] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - March 4, 2018 Category: Gastroenterology Tags: JOP Source Type: research

Efficacy of Endotherapy in the Treatment of Pain Associated With Chronic Pancreatitis: A Systematic Review and Meta-Analysis.
CONCLUSIONS: Endotherapy is beneficial for both immediate and long term management of pain associated with chronic pancreatitis. The efficacy of endotherapy decreases over time as assessed by evaluating pain relief on long term follow up. Given the considerable heterogeneity of reported data, additional prospective and standardized multicenter studies need to be conducted to evaluate the efficacy of this modality in controlling pain associated with chronic pancreatitis. PMID: 28966569 [PubMed - in process] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - October 4, 2017 Category: Gastroenterology Tags: JOP Source Type: research

The Role of Real Time Endoscopic Ultrasound Guided Elastography for Targeting EUS-FNA of Suspicious Pancreatic Masses: A Review of the Literature and A Single Center Experience.
CONCLUSIONS: In our single center experience we found that the use of real time endoscopic ultrasound guided elastography for targeting fine needle aspiration of suspicious pancreatic lesions may be beneficial as an adjunct modality to complement conventional EUS. Larger prospective studies need to be conducted to evaluate the utility of this modality in targeting pancreatic lesions. PMID: 28912670 [PubMed - in process] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - September 17, 2017 Category: Gastroenterology Tags: JOP Source Type: research

Confocal Endomicroscopy Characteristics of Different Intraductal Papillary Mucinous Neoplasm Subtypes.
Authors: Kamboj AK, Dewitt JM, Modi RM, Conwell DL, Krishna SG Abstract Intraductal papillary mucinous neoplasms are classified into gastric, intestinal, pancreatobiliary, and oncocytic subtypes where morphology portends disease prognosis. The study aim was to demonstrate EUS-guided needle-based confocal laser endomicroscopy imaging features of intraductal papillary mucinous neoplasm subtypes. Four subjects, each with a specific intraductal papillary mucinous neoplasm subtype were enrolled. An EUS-guided needle-based confocal laser endomicroscopy miniprobe was utilized for image acquisition. The mean cyst size from...
Source: Journal of the Pancreas - August 22, 2017 Category: Gastroenterology Tags: JOP Source Type: research

Is Total Pancreatectomy with Islet Autotransplantation A Reasonable Choice for Pediatric Pancreatitis?
Authors: Azhari H, Rahhal R, Uc A Abstract Chronic pancreatitis is an emerging and poorly understood disease in childhood. Total pancreatectomy with islet cell autotransplantation is being proposed as a treatment for chronic pancreatitis and recent studies report a more favorable outcome in children compared to adults. Herein, we review the therapeutic alternatives for pediatric chronic pancreatitis, focusing primarily on TP/IAT. PMID: 26523129 [PubMed] (Source: Journal of the Pancreas)
Source: Journal of the Pancreas - November 4, 2015 Category: Gastroenterology Tags: JOP Source Type: research