Impact of Metabolic Syndrome Diagnosis and Its Treatment on Survival of Colorectal Cancer Patients.
Conclusions: Our result suggests that, among CRC patients with MetS, taking metformin and statins may improve overall survival, whereas being on insulin may negatively impact CRC prognosis. Further studies are warranted to determine the exact mechanism through which metformin, statins, and insulin exert their effects on CRC survival. PMID: 31139216 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - May 30, 2019 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Stagnation in Decreasing Gastric Cancer Incidence and Mortality in Quito: Time Trend Analysis, 1985-2013.
Conclusions: The declines in incidence and mortality rates are stagnating. It is important to take measures to further reduce the high burden of GC. PMID: 30936917 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - April 3, 2019 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Use of Mastectomy for Overdiagnosed Breast Cancer in the United States: Analysis of the SEER 9 Cancer Registries.
Authors: Harding C, Pompei F, Burmistrov D, Wilson R Abstract Aim: We investigated use of mastectomy as treatment for early breast cancer in the US and applied the resulting information to estimate the minimum and maximum rates at which mastectomy could plausibly be undergone by patients with overdiagnosed breast cancer. Little is currently known about overtreatments undergone by overdiagnosed patients. Methods: In the US, screening is often recommended at ages ≥40. The study population was women age ≥40 diagnosed with breast cancer in the US SEER 9 cancer registries during 2013 (n=26,017). We evaluated f...
Source: Journal of Cancer Epidemiology - February 27, 2019 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

HPV-Chlamydial Coinfection, Prevalence, and Association with Cervical Intraepithelial Lesions: A Pilot Study at Mbarara Regional Referral Hospital.
Conclusion: HPV, Chlamydia, and HPV-Chlamydial coinfection are prevalent infections and there is a likelihood of association between HPV-Chlamydial coinfection and with cervical intraepithelial lesions. This study recommends general sexually transimitted infections (STIS) screening for every woman that turns up for cervical cancer screening and a larger study, probably a multicentre study. PMID: 30733803 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - February 10, 2019 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

A Community-Based Assessment of Knowledge and Practice of Breast Self-Examination and Prevalence of Breast Disease in Southwest Cameroon.
Conclusions: Socioeconomic disparities in access to health education may be a determinant of knowledge of BSE. Community-based strategies are needed to improve dissemination of breast cancer screening methods, particularly for women who face barriers to accessing care. PMID: 30713554 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - February 5, 2019 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Trends in Incidence of Two Major Subtypes of Liver and Bile Duct Cancer: Hepatocellular Carcinoma and Cholangiocarcinoma in Songkhla, Southern Thailand, 1989-2030.
Conclusions: The incidence of cholangiocarcinoma is expected to increase in Songkhla and will contribute a larger proportion of LBD cancers in the future. Future public health efforts and research studies should focus on this increasing trend. PMID: 30675163 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - January 25, 2019 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

The Epidemiology and Trend of Cancer in Jordan, 2000-2013.
Conclusion: Over the 14-year study period, incidence of cancer in Jordan has increased. However, it remains lower than that in other Eastern Mediterranean and Western countries. We recommend initiating screening programs for the most common types of cancer in Jordan that have valid screening tests to detect cancer during its early stages and reduce overall morbidity and mortality. PMID: 30416523 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - November 13, 2018 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Role of the Mechanisms of Detection in the Increased Risk of Thyroid Cancer: A Retrospective Cohort Study in an HMO in Buenos Aires.
Authors: Russo Picasso MF, Vicens J, Giuliani C, Jaén ADV, Cabezón C, Figari M, Gómez Saldaño AM, Figar S Abstract Background: Two hypotheses attempt to explain the increase of thyroid cancer (TC) incidence: overdetection by excessive diagnostic scrutiny and a true increase in new cases brought about by environmental factors. Changes in the mechanism of detection and the risk of incidentally diagnosed TC could result in an increase of TC incidence. Methods: Retrospective cohort study. We identified incident cases of TC from the pathological reports of patients in a HMO and review of ...
Source: Journal of Cancer Epidemiology - August 16, 2018 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Effects of Different Treatment Strategies and Tumor Stage on Survival of Patients with Advanced Laryngeal Carcinoma: A 15-Year Cohort Study.
Authors: Daneshi N, Fararouei M, Mohammadianpanah M, Zare-Bandamiri M, Parvin S, Dianatinasab M Abstract Background: Laryngeal cancer is the second most common cancer in the head and neck. Since laryngeal cancer management is a complex process, there is still no standard strategy to treat this disease in order to increase the survival rate of the patients especially among those with advanced form of the disease. Methods: A cohort study was undertaken to analyze factors predicting survival of the patients in advanced stage laryngeal cancer in the Southern Iran among all patients newly diagnosed with laryngeal ca...
Source: Journal of Cancer Epidemiology - July 7, 2018 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Validity of Administrative Databases in Comparison to Medical Charts for Breast Cancer Treatment Data.
This study will evaluate administrative data in comparison to medical charts for breast cancer treatment information. Study Design and Setting: A retrospective cohort design identified 2,401 women in the Ontario Breast Screening Program diagnosed with invasive breast cancer from 2006 to 2009. Treatment data were obtained from the Activity Level Reporting and Canadian Institute of Health Information databases. Medical charts were abstracted at cancer centres. Sensitivity, specificity, positive and negative predictive value, and kappa were calculated for receipt and type of treatment, and agreement was assessed for dates...
Source: Journal of Cancer Epidemiology - June 7, 2018 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Endocrine Therapy Initiation among Older Women with Ductal Carcinoma In Situ.
CONCLUSIONS: Less than half of older women with DCIS initiate endocrine therapy to prevent second breast cancers. Our findings suggest use was more common, but not exclusive, among women with ER-positive DCIS, but not among women who underwent BCS alone. Endocrine therapy should be targeted toward patients most likely to benefit from its use. PMID: 29056966 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - October 24, 2017 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Racial and Socioeconomic Disparities Are More Pronounced in Inflammatory Breast Cancer Than Other Breast Cancers.
We examined differences in patient demographics and outcomes in IBC compared to locally advanced breast cancer (LABC) and all other breast cancer patients from the Breast and Prostate Cancer Data Quality and Patterns of Care Study (POC-BP), containing information from cancer registries in seven states. Out of 7,624 cases of invasive carcinoma, IBC and LABC accounted for 2.2% (N = 170) and 4.9% (N = 375), respectively. IBC patients were more likely to have a higher number (P = 0.03) and severity (P = 0.01) of comorbidities than other breast cancer patients. Among IBC patients, a higher percentage of patients with metastatic...
Source: Journal of Cancer Epidemiology - September 14, 2017 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Prevalence of EGFR Mutations in Lung Cancer in Uruguayan Population.
CONCLUSIONS: This first epidemiological study of EGFR mutations in Uruguay reveals a wide spectrum of mutations and an overall prevalence of 18.3%. The background ethnic structure of the Uruguayan population could play an important role in explaining our findings. PMID: 28744312 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - July 28, 2017 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

The Role of Neighborhood Characteristics in Late Stage Melanoma Diagnosis among Hispanic Men in California, Texas, and Florida, 1996-2012.
CONCLUSION: The influence of contextual predictors on LSMD varied in magnitude and strength by state, highlighting both the cosegregation of social adversity and poverty and the complexity of their interactions. PMID: 28702054 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - July 15, 2017 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Insurance Status Is Related to Receipt of Therapy and Survival in Patients with Early-Stage Pancreatic Exocrine Carcinoma.
Authors: Boevers E, McDowell BD, Mott SL, Button AM, Lynch CF Abstract Objectives. The study objective was to determine how insurance status relates to treatment receipt and overall survival for patients with early-stage pancreatic exocrine carcinoma. Methods. SEER data were evaluated for 17,234 patients diagnosed with Stage I/II pancreatic exocrine carcinoma. Multivariate regression models controlled for personal characteristics to determine whether insurance status was independently associated with overall survival and receipt of radiation/surgery. Results. Odds of receiving radiation were 1.50 and 1.75 times hig...
Source: Journal of Cancer Epidemiology - May 11, 2017 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Relationships between Global DNA Methylation in Circulating White Blood Cells and Breast Cancer Risk Factors.
Authors: Chopra-Tandon N, Wu H, Arcaro KF, Sturgeon SR Abstract It is not yet clear whether white blood cell DNA global methylation is associated with breast cancer risk. In this review we examine the relationships between multiple breast cancer risk factors and three markers of global DNA methylation: LINE-1, 5-mdC, and Alu. A literature search was conducted using Pubmed up to April 1, 2016, using combinations of relevant outcomes such as "WBC methylation," "blood methylation," "blood LINE-1 methylation," and a comprehensive list of known and suspected breast cancer risk factors. Over...
Source: Journal of Cancer Epidemiology - May 10, 2017 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Cancer Prevention in Low- and Middle-Income Countries.
Authors: Dey S, Dhillon PK, Rajaraman P PMID: 28321255 [PubMed - in process] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - March 24, 2017 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Patterns of Sociodemographic and Clinicopathologic Characteristics of Stages II and III Colorectal Cancer Patients by Age: Examining Potential Mechanisms of Young-Onset Disease.
Authors: Murphy CC, Sanoff HK, Stitzenberg KB, Baron JA, Lund JL, Sandler RS Abstract Background and Aims. As a first step toward understanding the increasing incidence of colorectal cancer (CRC) in younger (age
Source: Journal of Cancer Epidemiology - February 28, 2017 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

A Case-Control Study of Risk Factors for Salivary Gland Cancer in Canada.
Conclusions. This study suggests positive associations with consumption of processed meat, smoking, obesity, alcohol drinking, and occupational exposure to radiation as well as negative associations with higher education, consumption of spinach/squash, and physical activity, which suggest a role of lifestyle factors in the etiology of salivary gland cancer. However, these findings were based on small number of cases and were nonsignificant. Further larger studies are warranted to confirm our findings. PMID: 28133481 [PubMed - in process] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - February 1, 2017 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Role of Private Enterprise in Cancer Control in Low to Middle Income Countries.
Conclusion. In LMICs, effective partnership between public and private institutions can lead to tangible strides in cancer control. The use of creative healthcare financing models can also support positive change. PMID: 28070189 [PubMed - in process] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - January 12, 2017 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Genetic and Clinical Features of Medullary Thyroid Carcinoma: The Experience of a Single Center in Costa Rica.
Conclusions. We report the results of RET mutation analysis in subjects with MTC in a single center of Costa Rica. The availability of this tool increases the probability of identifying familial MTC, with the benefit of detecting affected subjects and their relatives at an earlier age. PMID: 28018431 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - December 27, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Pattern and Distribution of Colorectal Cancer in Tanzania: A Retrospective Chart Audit at Two National Hospitals.
Conclusions. Age (P = 0.0183) and time (P = 0.004) but not gender (P = 0.0864) were significantly associated with rectal cancer in a retrospective study in Tanzania. Gender (P = 0.0405), age (P = 0.0015), and time (P = 0.0075) were all significantly associated with colon cancer in this study. This retrospective study found that colon cancer is more prevalent among males at a relatively younger age than rectal cancer. Further, our study showed that although more patients were diagnosed with rectal cancer, the trend has shown that colon cancer is increasing at a faster rate. PMID: 27965709 [PubMed - in process] (Source: ...
Source: Journal of Cancer Epidemiology - December 16, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Risk of Cancer among Commercially Insured HIV-Infected Adults on Antiretroviral Therapy.
The objective of this study was to explore the cancer incidence rates among HIV-infected persons with commercial insurance who were on antiretroviral therapy and compare them with those rates in the general population. Paid health insurance claims for 63,221 individuals 18 years or older, with at least one claim with a diagnostic code for HIV and at least one filled prescription for an antiretroviral medication between January 1, 2006, and September 30, 2012, were obtained from the LifeLink® Health Plan Claims Database. The expected number of cancer cases in the general population for each gender-age group (60 years) w...
Source: Journal of Cancer Epidemiology - November 26, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Screening of Oral Potentially Malignant Disorders Using Exfoliative Cytology: A Diagnostic Modality.
Discussion. When analyzed microscopically, 36 (90%) out of the 40 oral leukoplakic lesions showed Class II cytological features whereas 4 (10%) revealed Class I features. Among 40 patients with oral lichen planus, 26 (65%) showed Class II features while the remaining 14 (35%) revealed Class I features. In 40 subjects with oral submucous fibrosis, 32 (80%) showed Class II features while the other 8 (20%) showed Class I features. All the 40 control subjects showed Class I features. Thus, OEC can be widely advocated as an addition to clinical conclusion and an adjunct to biopsy. PMID: 27721828 [PubMed - in process] (Sourc...
Source: Journal of Cancer Epidemiology - October 12, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Breast Cancer Prevalence and Mortality among Hispanic Subgroups in the United States, 2009-2013.
Conclusion. The data reveal significant differences in mortality across Hispanic subgroups. These data enable public health officials to develop targeted interventions to help lower breast cancer mortality among the highest risk populations. PMID: 27672394 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - September 29, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Coffee Consumption and the Incidence of Colorectal Cancer in Women.
Authors: Groessl EJ, Allison MA, Larson JC, Ho SB, Snetslaar LG, Lane DS, Tharp KM, Stefanick ML Abstract Background. Higher coffee consumption has been associated with decreased incidence of colorectal cancer. Our objective was to examine the relationship of coffee intake to colorectal cancer incidence in a large observational cohort of postmenopausal US women. Methods. Data were collected for the Women's Health Initiative Observational Study providing a follow-up period of 12.9 years. The mean age of our sample (N = 83,778 women) was 63.5 years. Daily coffee intake was grouped into 3 categories: None, moderate (>0-
Source: Journal of Cancer Epidemiology - May 31, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Promoter Methylation and mRNA Expression of Response Gene to Complement 32 in Breast Carcinoma.
Conclusion. Our findings confirmed upregulation of RGC32 in breast cancerous tumors, but it was not associated with promoter methylation patterns. PMID: 27118972 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - April 29, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Prostate Cancer Screening in Jamaica: Results of the Largest National Screening Clinic.
Authors: Morrison BF, Aiken W, Mayhew R, Gordon Y, Reid M Abstract Prostate cancer is highly prevalent in Jamaica and is the leading cause of cancer-related deaths. Our aim was to evaluate the patterns of screening in the largest organized screening clinic in Jamaica at the Jamaica Cancer Society. A retrospective analysis of all men presenting for screening at the Jamaica Cancer Society from 1995 to 2005 was done. All patients had digital rectal examinations (DRE) and prostate specific antigen (PSA) tests done. Results of prostate biopsies were noted. 1117 men of mean age 59.9 ± 8.2 years presented for scree...
Source: Journal of Cancer Epidemiology - April 3, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

The Influences of Health Insurance and Access to Information on Prostate Cancer Screening among Men in Dominican Republic.
Conclusions. The expansion and restructuring of Dominican Republic universal health insurance scheme to ensure equity in access may improve health access that would potentially impact positively on prostate cancer screening among men. PMID: 27034669 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - April 3, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Determinants of Cervical Cancer Screening Uptake among Women in Ilorin, North Central Nigeria: A Community-Based Study.
This study assessed the determinants of cervical cancer screening uptake among Nigerian women. Methodology. This cross-sectional study was conducted using multistage sampling technique among 338 participants in Ilorin, North Central Nigeria. A pretested questionnaire was used for data collection and data analysis was done using SPSS version 21. Chi-square test was used for bivariate analysis while binary logistic regression was used for multivariate analysis. Statistical significance was set at p
Source: Journal of Cancer Epidemiology - February 19, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

What Prevents Men Aged 40-64 Years from Prostate Cancer Screening in Namibia?
Conclusions. A universal health insurance scheme may be necessary to increase uptake of prostate cancer screening. However it needs to be acknowledged that expanded screening can have negative consequences and any allocation of scarce resources towards screening must be guided by evidence obtained from the local context about the costs and benefits of screening. PMID: 26880917 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - February 19, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

The Prevalence of HIV in Cancer Patients at the Surgical Oncology Unit of Donka University Hospital of Conakry (Guinea).
Conclusion. HIV prevalence is higher in patients in our unit of surgical oncology. Breast cancer was the most common in this association. A national survey of a large sample is needed to determine the true prevalence and impact of HIV on cancer prognosis. PMID: 26770197 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - January 16, 2016 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Patterns of Benign and Malignant Lesions of the Thyroid in Two Wilayahs of Northeastern Algeria.
Authors: Guidoum M, Kherfi-Kadi H, Benharkat-Boughaba O, Djemaa-Bendjazia A, Keghouche S, Abedi-Ardekani B, Azzouz A, Kadi Y, Hainaut P, Bouslama Z Abstract The aim of this study is to compare histological patterns and to estimate the burden of thyroid cancers in the two Wilayahs (departments) of El-Taref and Guelma in northeast of Algeria (total population 0.9 million), locally reputed as having different rates of endemic thyroid diseases and cancer. A retrospective analysis of central pathology registers and clinical records of patients with thyroid diseases, covering the period 2008-2012, was conducted. A total ...
Source: Journal of Cancer Epidemiology - December 20, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Traditional Dietary Pattern Increases Risk of Prostate Cancer in Argentina: Results of a Multilevel Modeling and Bias Analysis from a Case-Control Study.
Authors: Niclis C, Román MD, Osella AR, Eynard AR, Díaz MD Abstract There is increasing evidence that dietary habits play a role in prostate cancer (PC) occurrence. Argentinean cancer risk studies require additional attention because of the singular dietary pattern of this population. A case-control study (147 PC cases, 300 controls) was conducted in Córdoba (Argentina) throughout 2008-2013. A principal component factor analysis was performed to identify dietary patterns. A mixed logistic regression model was applied, taking into account family history of cancer. Possible bias was evaluated by ...
Source: Journal of Cancer Epidemiology - December 11, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Incidence of Gastric Cancer in Marrakech and Casablanca, Morocco.
This study calculated age-specific, sex-specific, and total incidence rates of gastric cancer in Marrakech and was compared to the Casablanca population-based cancer registry. Using medical records from Center Hospital University Mohammad VI and reports from 4 main private pathology laboratories in Marrakech, we identified 774 patients for the period 2008-2012. Comparison of rates showed higher age-specific incidence in Marrakech in nearly all age groups for both genders. A higher total incidence in Marrakech than in Casablanca was found with rates of 5.50 and 3.23 per 100,000, respectively. Incidence was significantly hig...
Source: Journal of Cancer Epidemiology - November 18, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Occupational Exposure to Diesel Motor Exhaust and Lung Cancer: A Dose-Response Relationship Hidden by Asbestos Exposure Adjustment? The ICARE Study.
Conclusions. Exposure to DME and to asbestos is frequently found among the same subjects, which may explain why dose-response relationships in previous studies that adjusted for asbestos exposure were inconsistent. PMID: 26425123 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - October 3, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

The Influence of Socioeconomic Status on Racial/Ethnic Disparities among the ER/PR/HER2 Breast Cancer Subtypes.
Conclusions. Racial/ethnic disparities do not exist in all ER/PR/HER2 subtypes and, in general, SES modestly alters these disparities. PMID: 26339244 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - September 6, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Serum IGFBP-2 and Risk of Atypical Hyperplasia of the Breast.
Authors: Catsburg C, Gunter MJ, Tinker L, Chlebowski RT, Pollak M, Strickler HD, Cote ML, Page DL, Rohan TE Abstract Atypical hyperplasia of the breast (AH) is associated with increased risk of subsequent invasive breast cancer, yet little is known about the etiology of AH. Insulin-like growth factor binding protein 2 (IGFBP-2) may contribute to the development of AH due to its proliferative effects on mammary tissue. We conducted a nested case-control study of postmenopausal women enrolled in Women's Health Initiative-Clinical Trial. Cases were 275 women who developed incident AH during follow-up, individually (1&...
Source: Journal of Cancer Epidemiology - June 27, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Impact of Diabetes Status and Medication on Presentation, Treatment, and Outcome of Stage II Colon Cancer Patients.
Authors: Bae S, Wong HL, Tie J, Desai J, Field K, Kosmider S, Fourlanos S, Jones I, Skinner I, Gibbs P Abstract Diabetes is a risk factor for colorectal cancer and several reports suggest worse cancer-specific outcomes in diabetes patients. Recent studies in multiple tumour types indicate metformin may positively impact on cancer-specific and overall survival. A population-based series of stage II colorectal cancer patients treated and followed from 2000 to 2013 were analysed for baseline characteristics, treatment, and outcomes. 1116 patients with stage II colon cancer were identified, 55.5% were male and median a...
Source: Journal of Cancer Epidemiology - June 17, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Non-Small-Cell Lung Cancer Clinicopathologic Features and Survival Outcomes in Asian Pacific Islanders Residing in the United States: A SEER Analysis.
The objective of our study was to ascertain racial/ethnic disparities in Asian/Pacific Islanders (API) for non-small-cell lung cancer (NSCLC) clinicopathologic features and survival outcomes based on various tumor characteristics and treatment modalities. Method. SEER database identified invasive NSCLC cases from 2004 to 2010. Variables included American Joint Committee on Cancer (AJCC) stage 7, tumor grade, tumor size, histology, age, marital status, radiation, surgery, and reason for no surgery. The Kruskall-Wallis test and the Z test were used to examine differences between races/ethnicities and the referent, non-Hispan...
Source: Journal of Cancer Epidemiology - February 17, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Colorectal cancer in iran: molecular epidemiology and screening strategies.
Conclusion. Appropriate screening strategies for CRC which is amenable to early detection through screening, especially in relatives of CRCs, should be considered as the first step in CRC screening programs. PMID: 25685149 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - February 17, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

The Relationship between Eating and Lifestyle Habits and Cancer in Van Lake Region: Another Endemic Region for Esophageal and Gastric Cancers.
Authors: Celik S, Yılmaz EM, Özden F, Kotan C, Okut H Abstract Purpose. To examine the relationship between esophageal and gastric cancers commonly seen in Van Lake region and the traditional eating habits of the geography. Materials and Methods. Esophageal and gastric cancer cases, who underwent surgery between January 1, 2012, and December 31, 2013, were examined. Pathology reports of the patients and presence of Helicobacter pylori (HP) were recorded. Surveys were filled by face to face meeting or telephone call. Control group was created with randomly selected individuals without any cancer diagnosis havi...
Source: Journal of Cancer Epidemiology - February 6, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Increase in Distant Stage Breast Cancer Incidence Rates in US Women Aged 25-49 Years, 2000-2011: The Stage Migration Hypothesis.
Conclusions. Findings provide some support for stage migration as one explanation for the recent increase in incidence of distant stage breast cancer, but additional studies are needed using other databases. PMID: 25649489 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - February 6, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Cancer mortality pattern in lagos university teaching hospital, lagos, Nigeria.
Conclusion. The study shows that the cancers that accounted for majority of death occurred in organs that were accessible to screening procedures and not necessary for survival. We advise regular screening for precancerous lesions in these organs so as to reduce the mortality rate and burden of cancer. PMID: 25628656 [PubMed] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - February 1, 2015 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Incidence and Outcomes of Desmoplastic Small Round Cell Tumor: Results from the Surveillance, Epidemiology, and End Results Database.
Conclusion. DSRCT is more common in males and in people of African-American descent. Although overall survival remains poor, radiation therapy following surgery seems to improve outcome in these patients. PMID: 25431592 [PubMed - as supplied by publisher] (Source: Journal of Cancer Epidemiology)
Source: Journal of Cancer Epidemiology - November 30, 2014 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Single Nucleotide Polymorphisms in Selected Apoptotic Genes and BPDE-Induced Apoptotic Capacity in Apparently Normal Primary Lymphocytes: A Genotype-Phenotype Correlation Analysis.
Authors: Hu Z, Li C, Chen K, Wang LE, Sturgis EM, Spitz MR, Wei Q Abstract Apoptotic capacity (AC) in primary lymphocytes may be a marker for cancer susceptibility, and functional single nucleotide polymorphisms (SNPs) in genes involved in apoptotic pathways may modulate cellular AC in response to DNA damage. To further examine the correlation between apoptotic genotypes and phenotype, we genotyped 14 published SNPs in 11 apoptosis-related genes (i.e., p53, Bcl-2, BAX, CASP9, DR4, Fas, FasL, CASP8, CASP10, CASP3, and CASP7) and assessed the AC in response to benzo[a]pyrene-7,8-9,10-diol epoxide (BPDE) in cultured p...
Source: Journal of Cancer Epidemiology - November 18, 2014 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Genetic and epigenetic tumor suppressor gene silencing are distinct molecular phenotypes driven by growth promoting mutations in nonsmall cell lung cancer.
Authors: Marsit CJ, Houseman EA, Nelson HH, Kelsey KT Abstract Both genetic and epigenetic alterations characterize human nonsmall cell lung cancer (NSCLC), but the biological processes that create or select these alterations remain incompletely investigated. Our hypothesis posits that a roughly reciprocal relationship between the propensity for promoter hypermethylation and a propensity for genetic deletion leads to distinct molecular phenotypes of lung cancer. To test this hypothesis, we examined promoter hypermethylation of 17 tumor suppressor genes, as a marker of epigenetic alteration propensity, and deletion ...
Source: Journal of Cancer Epidemiology - November 18, 2014 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Correlation of DNA ploidy with progression of cervical cancer.
Authors: Singh M, Mehrotra S, Kalra N, Singh U, Shukla Y Abstract The majority of squamous cell carcinomas of cervix are preceded by visible changes in the cervix, most often detected by cervical smear. As cervical cancer is preceded by long precancerous stages, identification of the high-risk population through detection of DNA ploidy may be of importance in effective management of this disease. Here we attempted to correlate aneuploid DNA patterns and their influence on biological behavior of flow-cytometry analysis of DNA ploidy which was carried out in cytologically diagnosed cases of mild (79), moderate (36), ...
Source: Journal of Cancer Epidemiology - November 18, 2014 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Assessing Candidate Gene nsSNPs for Phenotypic Differences in Double-Strand Break Repair Using Radiation-Induced gammaH2A.X Foci.
Authors: Markunas CA, Umbach DM, Xu Z, Taylor JA Abstract Nonsynonymous SNPs (nsSNPs) in DNA repair genes may be important determinants of DNA damage and cancer risk. We applied a set of screening criteria to a large number of nsSNPs and selected a subset of SNPs that were likely candidates for phenotypic effects on DNA double-strand break repair (DSBR). In order to induce and follow DSBR, we exposed panels of cell lines to gamma irradiation and followed the formation and disappearance of gammaH2A.X foci over time. All panels of cell lines showed significant increases in number, intensity, and area of foci at both ...
Source: Journal of Cancer Epidemiology - November 18, 2014 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research

Predictors of venous thromboembolism in patients with advanced common solid cancers.
Authors: Hall IE, Andersen MS, Krumholz HM, Gross CP Abstract There is uncertainty about risk heterogeneity for venous thromboembolism (VTE) in older patients with advanced cancer and whether patients can be stratified according to VTE risk. We performed a retrospective cohort study of the linked Medicare-Surveillance, Epidemiology, and End Results cancer registry in older patients with advanced cancer of lung, breast, colon, prostate, or pancreas diagnosed between 1995-1999. We used survival analysis with demographics, comorbidities, and tumor characteristics/treatment as independent variables. Outcome was VTE dia...
Source: Journal of Cancer Epidemiology - November 18, 2014 Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research