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Development of an Interactive Web Application “Shiny App for Frequency Analysis on Homo sapiens Genome (SAFA-HsG)”
AbstractThe web application “Shiny App for Frequency Analysis onHomo sapiens Genome (SAFA-HsG) ” was developed using R programming-based bioconductor packages and shiny framework. Through the app, preliminary descriptive data analysis on nucleotide frequency, and CpG island, CpG non-island, and CpG island shores and shelves (downstream and upstream) of human reference genome can be carried out, which will help biologists to work on human epigenomics. Table view of these analyses of all chromosomes can be visualized and downloaded by the end users. Similarly, the respective comparative plots can be used for CpG sites co...
Source: Interdisciplinary Sciences, Computational Life Sciences - June 30, 2019 Category: Bioinformatics Source Type: research

Quantitative and Visual Characteristics of Primary Central Nervous System Lymphoma on 18 F-FDG-PET
In conclusion, aside from SUVmax andT/N values, other visual characteristics are also available to facilitate the differentiation of PCNSLs from other brain conditions on18F-FDG-PET scans. (Source: Interdisciplinary Sciences, Computational Life Sciences)
Source: Interdisciplinary Sciences, Computational Life Sciences - June 30, 2019 Category: Bioinformatics Source Type: research

Accelerated Versus Conventional Corneal Collagen Cross-Linking in the Treatment of Keratoconus: A Meta-analysis and Review of the Literature
ConclusionOur study demonstrated greater reductions ofKmean in the A-CXL group in comparison with the C-CXL group. Overall A-CXL is comparable to C-CXL from outcome basis. (Source: Interdisciplinary Sciences, Computational Life Sciences)
Source: Interdisciplinary Sciences, Computational Life Sciences - June 26, 2019 Category: Bioinformatics Source Type: research

Exploring the Influence of Parameters on the p53 Response When Single-Stranded Breaks and Double-Stranded Breaks Coexist
AbstractThe p53 response to DNA damage is closely related to cell fate decisions. P53 preferentially responds to single-stranded breaks (SSBs) exhibiting a graded response when single-stranded breaks (SSBs) and double-stranded breaks (DSBs) coexist. However, how p53 natural preferential response is affected by kinetic parameters remains to be elucidated. Here, based on the hybrid model I, we computationally searched all the parameters and parameter combinations in the parameter space to identify those that could alter the natural preferential response of p53 when SSBs and DSBs coexist. Firstly, when a single parameter is c...
Source: Interdisciplinary Sciences, Computational Life Sciences - June 19, 2019 Category: Bioinformatics Source Type: research

Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms
This study suggested extensive panels of novel therapeutic targets that are in charge of BC progression, hence their impressive role cannot be excluded and needs deeper empirical laboratory designs. (Source: Interdisciplinary Sciences, Computational Life Sciences)
Source: Interdisciplinary Sciences, Computational Life Sciences - June 10, 2019 Category: Bioinformatics Source Type: research