The VGNC: expanding standardized vertebrate gene nomenclature
The Vertebrate Gene Nomenclature Committee (VGNC) was established in 2016 as a sister project to the HUGO Gene Nomenclature Committee, to approve gene nomenclature in vertebrate species without an existing ded... (Source: Genome Biology)
Source: Genome Biology - May 12, 2023 Category: Genetics & Stem Cells Authors: Tamsin E. M. Jones, Bethan Yates, Bryony Braschi, Kristian Gray, Susan Tweedie, Ruth L. Seal and Elspeth A. Bruford Tags: Database Source Type: research
Decoding enhancer complexity with machine learning and high-throughput discovery
Enhancers are genomic DNA elements controlling spatiotemporal gene expression. Their flexible organization and functional redundancies make deciphering their sequence-function relationships challenging. This a... (Source: Genome Biology)
Source: Genome Biology - May 12, 2023 Category: Genetics & Stem Cells Authors: Gabrielle D. Smith, Wan Hern Ching, Paola Cornejo-P áramo and Emily S. Wong Tags: Review Source Type: research
Genome-wide association analysis reveals a novel pathway mediated by a dual-TIR domain protein for pathogen resistance in cotton
Verticillium wilt is one of the most devasting diseases for many plants, leading to global economic loss. Cotton is known to be vulnerable to its fungal pathogen, Verticillium dahliae, yet the related genetic mec... (Source: Genome Biology)
Source: Genome Biology - May 10, 2023 Category: Genetics & Stem Cells Authors: Yihao Zhang, Yaning Zhang, Xiaoyang Ge, Yuan Yuan, Yuying Jin, Ye Wang, Lihong Zhao, Xiao Han, Wei Hu, Lan Yang, Chenxu Gao, Xi Wei, Fuguang Li and Zhaoen Yang Tags: Research Source Type: research
Correcting gradient-based interpretations of deep neural networks for genomics
Post hoc attribution methods can provide insights into the learned patterns from deep neural networks (DNNs) trained on high-throughput functional genomics data. However, in practice, their resultant attributi... (Source: Genome Biology)
Source: Genome Biology - May 9, 2023 Category: Genetics & Stem Cells Authors: Antonio Majdandzic, Chandana Rajesh and Peter K. Koo Tags: Short Report Source Type: research
High-throughput deep learning variant effect prediction with Sequence UNET
Understanding coding mutations is important for many applications in biology and medicine but the vast mutation space makes comprehensive experimental characterisation impossible. Current predictors are often ... (Source: Genome Biology)
Source: Genome Biology - May 9, 2023 Category: Genetics & Stem Cells Authors: Alistair S. Dunham, Pedro Beltrao and Mohammed AlQuraishi Tags: Method Source Type: research
