New Pharmacologic Approaches to the Treatment of Bipolar Depression
AbstractDepression is the most commonly experienced mood state over the life span in individuals with bipolar disorder (BD) and is the primary driver of functional impairment and suicidality in BD. Despite this, there are few effective treatments for BD depression, with only a handful of atypical anti-psychotics and inconsistent evidence for traditional mood stabilizing agents. There have been few major ‘breakthroughs’ in the treatment of BD depression, and until recently, few agents that work via novel mechanisms of action to exert therapeutic effects. Here, we review treatments for BD depression which are emergent or...
Source: Drugs - May 25, 2023 Category: Drugs & Pharmacology Source Type: research
Zavegepant: First Approval
This article summarizes the milestones in the development of zavegepant leading to this first approval for the acute treatment of migraine with or without aura in adults. (Source: Drugs)
Source: Drugs - May 25, 2023 Category: Drugs & Pharmacology Source Type: research
New Pharmacologic Approaches to the Treatment of Bipolar Depression
AbstractDepression is the most commonly experienced mood state over the life span in individuals with bipolar disorder (BD) and is the primary driver of functional impairment and suicidality in BD. Despite this, there are few effective treatments for BD depression, with only a handful of atypical anti-psychotics and inconsistent evidence for traditional mood stabilizing agents. There have been few major ‘breakthroughs’ in the treatment of BD depression, and until recently, few agents that work via novel mechanisms of action to exert therapeutic effects. Here, we review treatments for BD depression which are emergent or...
Source: Drugs - May 25, 2023 Category: Drugs & Pharmacology Source Type: research
Zavegepant: First Approval
This article summarizes the milestones in the development of zavegepant leading to this first approval for the acute treatment of migraine with or without aura in adults. (Source: Drugs)
Source: Drugs - May 25, 2023 Category: Drugs & Pharmacology Source Type: research
Correction to: Eftrenonacog Alfa: A Review in Haemophilia B
(Source: Drugs)
Source: Drugs - May 24, 2023 Category: Drugs & Pharmacology Source Type: research
The Effect of Biological Treatment on Fatigue in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
ConclusionBiological and small molecule drugs used in inflammatory bowel disease have a consistent, though small, beneficial effect on fatigue. (Source: Drugs)
Source: Drugs - May 23, 2023 Category: Drugs & Pharmacology Source Type: research
Rezafungin: First Approval
This article summarizes the milestones in the development of rezafungin leading to the first approval for t he treatment of candidaemia and invasive candidiasis. (Source: Drugs)
Source: Drugs - May 22, 2023 Category: Drugs & Pharmacology Source Type: research
Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics
AbstractAs clinical use of currently available opioid analgesics is often impeded by dose-limiting adverse effects, such as abuse liability and respiratory depression, new approaches have been pursued to develop safe, effective, and non-addictive pain medications. After the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor more than 25 years ago, NOP receptor-related agonists have emerged as a promising target for developing novel and effective opioids that modulate the analgesic and addictive properties of mu-opioid peptide (MOP) receptor agonists. In this review, we highlight the effects of the ...
Source: Drugs - May 20, 2023 Category: Drugs & Pharmacology Source Type: research
Correction to: Recent Human Papillomavirus Vaccination is Associated with a Lower Risk of COVID-19: A US Database Cohort Study
(Source: Drugs)
Source: Drugs - May 19, 2023 Category: Drugs & Pharmacology Source Type: research
