Combined Hemoperfusion-Hemodialysis in End-Stage Renal Disease Patients
Contrib Nephrol. 2023 Jun 1;200:1-5. doi: 10.1159/000527953. Online ahead of print.ABSTRACTDespite advances in dialysis technology, a high level of morbidity and mortality is still present in end-stage renal disease patients undergoing maintenance dialysis. This has been in great part correlated with accumulation of uremic toxins that cannot be adequately removed by classic dialysis membranes and techniques. Improvements have been made in enhancing both membrane permeability and convection rates as in the case for expanded hemodialysis (HD) and hemodiafiltration, but these techniques still present limitations or cannot be ...
Source: Contributions to Nephrology - June 1, 2023 Category: Urology & Nephrology Authors: Claudio Ronco Source Type: research
Hemoperfusion in Leptospirosis
Contrib Nephrol. 2023 Jun 1;200:1-10. doi: 10.1159/000527571. Online ahead of print.ABSTRACTLeptospirosis is the most common zoonosis frequently seen in the tropics and subtropics especially during the rainy season when humans wade in floods contaminated by the urine of infected rats in urban areas. Aside from direct toxicity of the leptospires, the role of an exuberant immune response to the pathogen leading to secondary organ damage has been recognized. Thus, our treatment protocol for patients with severe leptospirosis characterized by renal failure, acute liver injury, and lung hemorrhage now includes a short course of...
Source: Contributions to Nephrology - June 1, 2023 Category: Urology & Nephrology Authors: Romina A Danguilan Source Type: research
Hemoperfusion with CytoSorb ®: Current Knowledge on Patient Selection, Timing, and Dosing
Contrib Nephrol. 2023 Jun 1;200:1-8. doi: 10.1159/000527774. Online ahead of print.ABSTRACTDirect hemoperfusion with the CytoSorb® adsorbent has experienced widespread use in several critical care settings including sepsis and multiorgan failure. The reported conditions of clinical usage and resulting outcomes vary considerably. The aim of the study was to provide an overview on current treatment recommendations based on the available clinical evidence. We performed a literature analysis using PubMed/MEDLINE and ClinicalTrials.gov to identify clinical data describing parameters of clinical usage of CytoSorb® in patients ...
Source: Contributions to Nephrology - June 1, 2023 Category: Urology & Nephrology Authors: Gerd Klinkmann Sebastian Koball Daniel A Reuter Steffen Mitzner Source Type: research
Update on the Role of Polymethylmethacrylate Membrane Hemofilter in Acute and Chronic Renal Dysfunction
Contrib Nephrol. 2023 Jun 1;200:1-10. doi: 10.1159/000530476. Online ahead of print.ABSTRACTDespite recent technical advances in dialysis care over the past decades, the mortality rate of critically ill patients with acute kidney injury (AKI) requiring dialysis and of chronic kidney disease (CKD) remains unacceptably high. Several preclinical studies have increased our knowledge of the principal mechanisms involved in the pathophysiology of AKI and CKD. Additionally, the development of efficient and specific compensatory sorbent systems in renal replacement therapy to remove unwanted compounds has created the possibility t...
Source: Contributions to Nephrology - June 1, 2023 Category: Urology & Nephrology Authors: Alessandra Stasi Rossana Franzin Rosa Losapio Carlo Alfieri Loreto Gesualdo Giuseppe Castellano Source Type: research
Hemoperfusion and Immunomodulation
Contrib Nephrol. 2023 Jun 1;200:1-7. doi: 10.1159/000529885. Online ahead of print.ABSTRACTRecent development in sorbent technology has spurred new interest in the potential of hemoperfusion (HP) in clinical conditions such as cytokine release syndromes and sepsis. Although the role of nonselective HP in such conditions requires solid evidence and more studies, the rationale for clinical application is clearly emerging. Greater biocompatibility and safety of the new sorbents may allow easy and safe application of HP in those conditions where the innate and the adaptive immune response of the individual appears to be dysreg...
Source: Contributions to Nephrology - June 1, 2023 Category: Urology & Nephrology Authors: Claudio Ronco Sara Samoni Rinaldo Bellomo Source Type: research
