Erratum to: The Developing Human Connectome Project: typical and disrupted perinatal functional connectivity
Michael Eyre, Sean P. Fitzgibbon, Judit Ciarrusta, Lucilio Cordero-Grande, Anthony N. Price, Tanya Poppe, Andreas Schuh, Emer Hughes, Camilla O ’Keeffe, Jakki Brandon, Daniel Cromb, Katy Vecchiato, Jesper Andersson, Eugene P. Duff, Serena J. Counsell, Stephen M. Smith, Daniel Rueckert, Joseph V. Hajnal, Tomoki Arichi, Jonathan O’Muircheartaigh, Dafnis Batalle, A. David Edwards. The Developing Human Connectome Project: typical and disrup ted perinatal functional connectivity.Brain 2021;awab118. doi:10.1093/brain/awab118 (Source: Brain)
Source: Brain - July 5, 2021 Category: Neurology Source Type: research
Corrigendum to: CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer ’s disease
Kanta Horie, Nicolas R. Barth élemy, Chihiro Sato, Randall J. Bateman. CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer’s disease.Brain 2021;144:515 –527. doi:10.1093/brain/awaa373 (Source: Brain)
Source: Brain - July 3, 2021 Category: Neurology Source Type: research
Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson ’s disease
We examined 93 subjects (40 healthy controls and 53 Parkinson’s disease patients) with neuromelanin-sensitive turbo spin-echo MRI and calculated locus coeruleus-to-pons signal contrasts. Voxels with the highest intensities were extracted from published locus coerule us coordinates transformed to individual MRI. To also investigate a potential spatial pattern of locus coeruleus degeneration, we extracted the highest signal intensities from the rostral, middle, and caudal third of the locus coeruleus. Additionally, a study-specific probabilistic map of the locus coeruleus was created and used to extract mean MRI contrast f...
Source: Brain - July 1, 2021 Category: Neurology Source Type: research
MATR3 haploinsufficiency and early-onset neurodegeneration
German Research FoundationDeutsche Forschungsgemeinschaft10.13039/501100001659DI 1731/2-2Elterninitiative Kinderkrebsklinik#701900167 (Source: Brain)
Source: Brain - June 26, 2021 Category: Neurology Source Type: research
Erratum to: Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation
Katerina Hristova, Cristina Martinez-Gonzalez, Thomas C. Watson, Neela K. Codadu, Kevan Hashemi, Peter C. Kind, Matthew F. Nolan and Alfredo Gonzalez-Sulser. Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation.Brain. 2021;144(5):1576-1589. doi:10.1093/brain/awab042 (Source: Brain)
Source: Brain - June 25, 2021 Category: Neurology Source Type: research
Myopathic mitochondrial DNA depletion syndrome associated with biallelic variants in LIG3
BMBF10.13039/50110000234701GM1920AItalian MoHJ42F19000030006-RE17Horizon 202010.13039/100010661N °825575European Joint Programme on Rare DiseasesBMBF10.13039/50110000234701KU2016AItalian MoHJ49C2000019000-RE15ERA PerMed project PerMiMGerman Network for Mitochondrial Disorders01GM1906DCenter for the Study of Mitochondrial Pediatric Diseases fundedLuisa Mariani Foundation (Source: Brain)
Source: Brain - June 24, 2021 Category: Neurology Source Type: research
Studying human nociceptors: from fundamentals to clinic
AbstractChronic pain affects one in five of the general population and is the third most important cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate due to poor efficacy and tolerability. There has been a failure in translating promising preclinical drug targets into clinic use. This reflects challenges across the whole drug development pathway, from preclinical models to trial design. Nociceptors remain an attractive therapeutic target: their sensitization makes an important contribution to many chronic pain states, they are located outside the blood –brain barrier, and they a...
Source: Brain - June 21, 2021 Category: Neurology Source Type: research
Annexin A1 restores cerebrovascular integrity concomitant with reduced amyloid- β and tau pathology
AbstractAlzheimer ’s disease, characterized by brain deposits of amyloid-β plaques and neurofibrillary tangles, is also linked to neurovascular dysfunction and blood–brain barrier breakdown, affecting the passage of substances into and out of the brain. We hypothesized that treatment of neurovascular alterations could be beneficial in Alzheimer’s disease. Annexin A1 (ANXA1) is a mediator of glucocorticoid anti-inflammatory action that can suppress microglial activation and reduce blood–brain barrier leakage. We have reported recently that treatment with recombinant human ANXA1 (hrANXA1) reduced amyloid -β levels ...
Source: Brain - June 21, 2021 Category: Neurology Source Type: research
Preventing neurodegenerative disease
As a person ages, the brunt of illness falls increasingly on systems that have limited ability to repair or maintain themselves. Neurons, being post-mitotic, are particularly sensitive in this regard, and the outcome manifests in the increasing prevalence of neurodegenerative disease as the mean age of the population rises. For the individual experiencing a slowing of movement, wasting of a limb, tremor or a failing memory, the onset of symptoms appears to mark the onset of the underlying problem, and people often try to attribute cause based on recent events —‘It all started after the operation’, ‘I was fine until...
Source: Brain - June 21, 2021 Category: Neurology Source Type: research
MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response
AbstractAutoantibodies are a hallmark of numerous neurological disorders, including multiple sclerosis, autoimmune encephalitides and neuromyelitis optica. Whilst well understood in peripheral myeloid cells, the pathophysiological significance of autoantibody-induced Fc receptor signalling in microglia remains unknown, in part due to the lack of a robustin vivo model. Moreover, the application of therapeutic antibodies for neurodegenerative disease also highlights the importance of understanding Fc receptor signalling in microglia.Here, we describe a novelin vivo experimental paradigm that allows for selective engagement o...
Source: Brain - June 19, 2021 Category: Neurology Source Type: research
From early limbic inflammation to long COVID sequelae
APHMNCT00484523 (Source: Brain)
Source: Brain - June 17, 2021 Category: Neurology Source Type: research
Reply: From early limbic inflammation to long COVID sequelae
(Source: Brain)
Source: Brain - June 17, 2021 Category: Neurology Source Type: research
Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction
AbstractAxonal Charcot-Marie-Tooth neuropathies (CMT type 2) are caused by inherited mutations in various genes functioning in different pathways. The types of genes and multiplicity of mutations reflect the clinical and genetic heterogeneity in CMT2 disease, which complicates its diagnosis and has inhibited the development of therapies. Here, we used CMT2 patient-derived pluripotent stem cells (iPSCs) to identify common hallmarks of axonal degeneration shared by different CMT2 subtypes. We compared the cellular phenotypes of neurons differentiated from CMT2 patient iPSCs with those from healthy controls and a CRISPR/Cas9-...
Source: Brain - June 15, 2021 Category: Neurology Source Type: research
Corrigendum to: Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation
Takashi Tsuboi, Joshua K. Wong, Robert S. Eisinger, Lela Okromelidze, Mathew R. Burns, Adolfo Ramirez-Zamora, Leonardo Almeida, Aparna Wagle Shukla, Kelly D. Foote, Michael S. Okun, Sanjeet S. Grewal and Erik H. Middlebrooks. Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation.Brain 2021;144(6):1774 –1786. doi:10.1093/brain/awab074 (Source: Brain)
Source: Brain - June 11, 2021 Category: Neurology Source Type: research
Erratum to: Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies
Hugo Vicente Miranda, Éva M. Szegő, Luís M. A. Oliveira, Carlo Breda, Ekrem Darendelioglu, Rita M. de Oliveira, Diana G. Ferreira, Marcos A. Gomes, Ruth Rott, Márcia Oliveira, Francesca Munari, Francisco J. Enguita, Tânia Simões, Eva F. Rodrigues, Michael Heinrich, Ivo C. Martins, Irina Zamolo, Olaf Riess, Carlos C ordeiro, Ana Ponces-Freire, Hilal A. Lashuel, Nuno C. Santos, Luisa V. Lopes, Wei Xiang, Thomas M. Jovin, Deborah Penque, Simone Engelender, Markus Zweckstetter, Jochen Klucken, Flaviano Giorgini, Alexandre Quintas, Tiago F. Outeiro. Glycation potentiates α-synuclein-associated neurodegeneration in synucl...
Source: Brain - June 8, 2021 Category: Neurology Source Type: research
