Annual Review of Genomics and Human Genetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The < em > Myriad < /em > Decision at 10
Annu Rev Genomics Hum Genet. 2024 Feb 29. doi: 10.1146/annurev-genom-010323-011239. Online ahead of print.ABSTRACTA decade ago, the US Supreme Court decided Association for Molecular Pathology v. Myriad Genetics, Inc., concluding that isolated genes were not patentable subject matter. Beyond being a mere patent dispute, the case was a political and cultural phenomenon, viewed as a harbinger for the health of the biotechnology industry. With a decade of perspective, though, Myriad's impact seems much narrower. The law surrounding patentable subject matter-while greatly transformed-only centered on Myriad in small part. The ...
Source: Annual Review of Genomics and Human Genetics - February 29, 2024 Category: Genetics & Stem Cells Authors: Jacob S Sherkow Robert Cook-Deegan Henry T Greely Source Type: research

Population Diversity at the Single-Cell Level
Annu Rev Genomics Hum Genet. 2024 Feb 21. doi: 10.1146/annurev-genom-021623-083207. Online ahead of print.ABSTRACTPopulation-scale single-cell genomics is a transformative approach for unraveling the intricate links between genetic and cellular variation. This approach is facilitated by cutting-edge experimental methodologies, including the development of high-throughput single-cell multiomics and advances in multiplexed environmental and genetic perturbations. Examining the effects of natural or synthetic genetic variants across cellular contexts provides insights into the mutual influence of genetics and the environment ...
Source: Annual Review of Genomics and Human Genetics - February 21, 2024 Category: Genetics & Stem Cells Authors: M Grace Gordon Pooja Kathail Bryson Choy Min Cheol Kim Thomas Mazumder Melissa Gearing Chun Jimmie Ye Source Type: research

RNA Sequencing in Disease Diagnosis
Annu Rev Genomics Hum Genet. 2024 Feb 15. doi: 10.1146/annurev-genom-021623-121812. Online ahead of print.ABSTRACTRNA sequencing (RNA-seq) enables the accurate measurement of multiple transcriptomic phenotypes for modeling the impacts of disease variants. Advances in technologies, experimental protocols, and analysis strategies are rapidly expanding the application of RNA-seq to identify disease biomarkers, tissue- and cell-type-specific impacts, and the spatial localization of disease-associated mechanisms. Ongoing international efforts to construct biobank-scale transcriptomic repositories with matched genomic data acros...
Source: Annual Review of Genomics and Human Genetics - February 15, 2024 Category: Genetics & Stem Cells Authors: Craig Smail Stephen B Montgomery Source Type: research