Highly selective fluorescent probe with an ideal pH profile for the rapid and unambiguous determination of subcellular labile iron (III) pools in human cells
Anal Lett. 2022;55(12):1954-1970. doi: 10.1080/00032719.2022.2039932. Epub 2022 Mar 31.ABSTRACTA convenient tool for detecting iron ions in subcellular structures is desired for better understanding its roles in biological systems. In this work, a new Fe3+ sensor, 2-(2-((1-(6-acetylpyridin-2-yl)ethylidene)amino)ethyl)-3',6'-bis(diethylamino)spiro[isoindoline-1,9'-xanthen]-3-one (RhPK), which operates across the entire cellular pH range and is capable of unambiguously detecting Fe3+ ion in live human cells at subcellular resolution, is reported. The sensor exhibits high selectivity and sensitivity toward Fe3+ with a rapid f...
Source: Analytical Letters - October 31, 2022 Category: Chemistry Authors: Bayan Alhawsah Bing Yan Ziya Aydin Xiangyu Niu Maolin Guo Source Type: research