Multiple regulatory mechanisms for pH homeostasis in the gastric pathogen, Helicobacter pylori
Adv Genet. 2022;109:39-69. doi: 10.1016/bs.adgen.2022.07.001. Epub 2022 Aug 18.ABSTRACTAcid-resistance in gastric pathogen Helicobacter pylori requires the coordination of four essential processes to regulate urease activity. Firstly, urease expression above a base level needs to be finely tuned at different ambient pH. Secondly, as nickel is needed to activate urease, nickel homeostasis needs to be maintained by proteins that import and export nickel ions, and sequester, store and release nickel when needed. Thirdly, urease accessary proteins that activate urease activity by nickel insertion need to be expressed. Finally,...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Xuhua Xia Source Type: research
RecBCD enzyme and Chi recombination hotspots as determinants of self vs. non-self: Myths and mechanisms
Adv Genet. 2022;109:1-37. doi: 10.1016/bs.adgen.2022.06.001. Epub 2022 Sep 2.ABSTRACTBacteria face a challenge when DNA enters their cells by transformation, mating, or phage infection. Should they treat this DNA as an invasive foreigner and destroy it, or consider it one of their own and potentially benefit from incorporating new genes or alleles to gain useful functions? It is frequently stated that the short nucleotide sequence Chi (5' GCTGGTGG 3'), a hotspot of homologous genetic recombination recognized by Escherichia coli's RecBCD helicase-nuclease, allows E. coli to distinguish its DNA (self) from any other DNA (non...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Suriyen Subramaniam Gerald R Smith Source Type: research
Multiple regulatory mechanisms for pH homeostasis in the gastric pathogen, Helicobacter pylori
Adv Genet. 2022;109:39-69. doi: 10.1016/bs.adgen.2022.07.001. Epub 2022 Aug 18.ABSTRACTAcid-resistance in gastric pathogen Helicobacter pylori requires the coordination of four essential processes to regulate urease activity. Firstly, urease expression above a base level needs to be finely tuned at different ambient pH. Secondly, as nickel is needed to activate urease, nickel homeostasis needs to be maintained by proteins that import and export nickel ions, and sequester, store and release nickel when needed. Thirdly, urease accessary proteins that activate urease activity by nickel insertion need to be expressed. Finally,...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Xuhua Xia Source Type: research
RecBCD enzyme and Chi recombination hotspots as determinants of self vs. non-self: Myths and mechanisms
Adv Genet. 2022;109:1-37. doi: 10.1016/bs.adgen.2022.06.001. Epub 2022 Sep 2.ABSTRACTBacteria face a challenge when DNA enters their cells by transformation, mating, or phage infection. Should they treat this DNA as an invasive foreigner and destroy it, or consider it one of their own and potentially benefit from incorporating new genes or alleles to gain useful functions? It is frequently stated that the short nucleotide sequence Chi (5' GCTGGTGG 3'), a hotspot of homologous genetic recombination recognized by Escherichia coli's RecBCD helicase-nuclease, allows E. coli to distinguish its DNA (self) from any other DNA (non...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Suriyen Subramaniam Gerald R Smith Source Type: research
Multiple regulatory mechanisms for pH homeostasis in the gastric pathogen, Helicobacter pylori
Adv Genet. 2022;109:39-69. doi: 10.1016/bs.adgen.2022.07.001. Epub 2022 Aug 18.ABSTRACTAcid-resistance in gastric pathogen Helicobacter pylori requires the coordination of four essential processes to regulate urease activity. Firstly, urease expression above a base level needs to be finely tuned at different ambient pH. Secondly, as nickel is needed to activate urease, nickel homeostasis needs to be maintained by proteins that import and export nickel ions, and sequester, store and release nickel when needed. Thirdly, urease accessary proteins that activate urease activity by nickel insertion need to be expressed. Finally,...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Xuhua Xia Source Type: research
RecBCD enzyme and Chi recombination hotspots as determinants of self vs. non-self: Myths and mechanisms
Adv Genet. 2022;109:1-37. doi: 10.1016/bs.adgen.2022.06.001. Epub 2022 Sep 2.ABSTRACTBacteria face a challenge when DNA enters their cells by transformation, mating, or phage infection. Should they treat this DNA as an invasive foreigner and destroy it, or consider it one of their own and potentially benefit from incorporating new genes or alleles to gain useful functions? It is frequently stated that the short nucleotide sequence Chi (5' GCTGGTGG 3'), a hotspot of homologous genetic recombination recognized by Escherichia coli's RecBCD helicase-nuclease, allows E. coli to distinguish its DNA (self) from any other DNA (non...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Suriyen Subramaniam Gerald R Smith Source Type: research
Multiple regulatory mechanisms for pH homeostasis in the gastric pathogen, Helicobacter pylori
Adv Genet. 2022;109:39-69. doi: 10.1016/bs.adgen.2022.07.001. Epub 2022 Aug 18.ABSTRACTAcid-resistance in gastric pathogen Helicobacter pylori requires the coordination of four essential processes to regulate urease activity. Firstly, urease expression above a base level needs to be finely tuned at different ambient pH. Secondly, as nickel is needed to activate urease, nickel homeostasis needs to be maintained by proteins that import and export nickel ions, and sequester, store and release nickel when needed. Thirdly, urease accessary proteins that activate urease activity by nickel insertion need to be expressed. Finally,...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Xuhua Xia Source Type: research
RecBCD enzyme and Chi recombination hotspots as determinants of self vs. non-self: Myths and mechanisms
Adv Genet. 2022;109:1-37. doi: 10.1016/bs.adgen.2022.06.001. Epub 2022 Sep 2.ABSTRACTBacteria face a challenge when DNA enters their cells by transformation, mating, or phage infection. Should they treat this DNA as an invasive foreigner and destroy it, or consider it one of their own and potentially benefit from incorporating new genes or alleles to gain useful functions? It is frequently stated that the short nucleotide sequence Chi (5' GCTGGTGG 3'), a hotspot of homologous genetic recombination recognized by Escherichia coli's RecBCD helicase-nuclease, allows E. coli to distinguish its DNA (self) from any other DNA (non...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Suriyen Subramaniam Gerald R Smith Source Type: research
Multiple regulatory mechanisms for pH homeostasis in the gastric pathogen, Helicobacter pylori
Adv Genet. 2022;109:39-69. doi: 10.1016/bs.adgen.2022.07.001. Epub 2022 Aug 18.ABSTRACTAcid-resistance in gastric pathogen Helicobacter pylori requires the coordination of four essential processes to regulate urease activity. Firstly, urease expression above a base level needs to be finely tuned at different ambient pH. Secondly, as nickel is needed to activate urease, nickel homeostasis needs to be maintained by proteins that import and export nickel ions, and sequester, store and release nickel when needed. Thirdly, urease accessary proteins that activate urease activity by nickel insertion need to be expressed. Finally,...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Xuhua Xia Source Type: research
RecBCD enzyme and Chi recombination hotspots as determinants of self vs. non-self: Myths and mechanisms
Adv Genet. 2022;109:1-37. doi: 10.1016/bs.adgen.2022.06.001. Epub 2022 Sep 2.ABSTRACTBacteria face a challenge when DNA enters their cells by transformation, mating, or phage infection. Should they treat this DNA as an invasive foreigner and destroy it, or consider it one of their own and potentially benefit from incorporating new genes or alleles to gain useful functions? It is frequently stated that the short nucleotide sequence Chi (5' GCTGGTGG 3'), a hotspot of homologous genetic recombination recognized by Escherichia coli's RecBCD helicase-nuclease, allows E. coli to distinguish its DNA (self) from any other DNA (non...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Suriyen Subramaniam Gerald R Smith Source Type: research
Multiple regulatory mechanisms for pH homeostasis in the gastric pathogen, Helicobacter pylori
Adv Genet. 2022;109:39-69. doi: 10.1016/bs.adgen.2022.07.001. Epub 2022 Aug 18.ABSTRACTAcid-resistance in gastric pathogen Helicobacter pylori requires the coordination of four essential processes to regulate urease activity. Firstly, urease expression above a base level needs to be finely tuned at different ambient pH. Secondly, as nickel is needed to activate urease, nickel homeostasis needs to be maintained by proteins that import and export nickel ions, and sequester, store and release nickel when needed. Thirdly, urease accessary proteins that activate urease activity by nickel insertion need to be expressed. Finally,...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Xuhua Xia Source Type: research
RecBCD enzyme and Chi recombination hotspots as determinants of self vs. non-self: Myths and mechanisms
Adv Genet. 2022;109:1-37. doi: 10.1016/bs.adgen.2022.06.001. Epub 2022 Sep 2.ABSTRACTBacteria face a challenge when DNA enters their cells by transformation, mating, or phage infection. Should they treat this DNA as an invasive foreigner and destroy it, or consider it one of their own and potentially benefit from incorporating new genes or alleles to gain useful functions? It is frequently stated that the short nucleotide sequence Chi (5' GCTGGTGG 3'), a hotspot of homologous genetic recombination recognized by Escherichia coli's RecBCD helicase-nuclease, allows E. coli to distinguish its DNA (self) from any other DNA (non...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Suriyen Subramaniam Gerald R Smith Source Type: research
Multiple regulatory mechanisms for pH homeostasis in the gastric pathogen, Helicobacter pylori
Adv Genet. 2022;109:39-69. doi: 10.1016/bs.adgen.2022.07.001. Epub 2022 Aug 18.ABSTRACTAcid-resistance in gastric pathogen Helicobacter pylori requires the coordination of four essential processes to regulate urease activity. Firstly, urease expression above a base level needs to be finely tuned at different ambient pH. Secondly, as nickel is needed to activate urease, nickel homeostasis needs to be maintained by proteins that import and export nickel ions, and sequester, store and release nickel when needed. Thirdly, urease accessary proteins that activate urease activity by nickel insertion need to be expressed. Finally,...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Xuhua Xia Source Type: research
RecBCD enzyme and Chi recombination hotspots as determinants of self vs. non-self: Myths and mechanisms
Adv Genet. 2022;109:1-37. doi: 10.1016/bs.adgen.2022.06.001. Epub 2022 Sep 2.ABSTRACTBacteria face a challenge when DNA enters their cells by transformation, mating, or phage infection. Should they treat this DNA as an invasive foreigner and destroy it, or consider it one of their own and potentially benefit from incorporating new genes or alleles to gain useful functions? It is frequently stated that the short nucleotide sequence Chi (5' GCTGGTGG 3'), a hotspot of homologous genetic recombination recognized by Escherichia coli's RecBCD helicase-nuclease, allows E. coli to distinguish its DNA (self) from any other DNA (non...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Suriyen Subramaniam Gerald R Smith Source Type: research
Multiple regulatory mechanisms for pH homeostasis in the gastric pathogen, Helicobacter pylori
Adv Genet. 2022;109:39-69. doi: 10.1016/bs.adgen.2022.07.001. Epub 2022 Aug 18.ABSTRACTAcid-resistance in gastric pathogen Helicobacter pylori requires the coordination of four essential processes to regulate urease activity. Firstly, urease expression above a base level needs to be finely tuned at different ambient pH. Secondly, as nickel is needed to activate urease, nickel homeostasis needs to be maintained by proteins that import and export nickel ions, and sequester, store and release nickel when needed. Thirdly, urease accessary proteins that activate urease activity by nickel insertion need to be expressed. Finally,...
Source: Advances in Genetics - November 5, 2022 Category: Genetics & Stem Cells Authors: Xuhua Xia Source Type: research
