Recent advances in trichotillomania: a narrative review
Acta Dermatovenerol Alp Pannonica Adriat. 2023 Dec;32(4):151-157.ABSTRACTTrichotillomania, defined as the compulsive pulling out of one's hair, is a psychocutaneous condition associated with functional impairment and decreased quality of life. The pathophysiology of trichotillomania is poorly understood and likely multifactorial, involving alterations in both neural activity and cognitive function. Behavioral treatment options for trichotillomania are limited and are often only modestly effective. Moreover, there are no medications currently approved by the U.S. Food and Drug Administration for its treatment. The gaps in k...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Rachel E Christensen Isabella Tan Mohammad Jafferany Source Type: research

New anti-aging strategies: a narrative review
The objective of anti-aging medicine is to decelerate the aging process and mitigate its associated effects, such as susceptibility to cancer, diabetes, and cardiovascular and neurodegenerative diseases. This review provides an overview of the latest advancements in this field, considering both pharmaceutical and non-pharmaceutical approaches. Electronic literature search involved three databases: MEDLINE, Cochrane, and Google Scholar, supplemented by other available literature. Strategies for delaying aging and related diseases comprise pharmaceutical interventions and lifestyle choices. It is crucial for these strategies...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Vana Stoji ć Tea Štrbac Andrija Stanimirovi ć Source Type: research

Different skin wart types, different human papillomavirus types? A narrative review
Acta Dermatovenerol Alp Pannonica Adriat. 2023 Dec;32(4):165-171.ABSTRACTSkin warts are ubiquitous, self-limiting, benign neoplasms caused by human papillomaviruses (HPV). Several studies have investigated the prevalence and diversity of HPV types in the three main types of skin warts: common, plantar, and flat warts. Using different methodological approaches and diverse populations, several HPV types were detected in skin warts, but often the etiological link remained unconfirmed. This review addresses recently improved multiple strategies for investigating the presence of HPVs in skin warts, covering proper sampling tech...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Lucijan Skubic Vesna Breznik Mario Poljak Source Type: research

Cutaneous manifestations of the COVID-19 pandemic in schoolchildren and adolescents
Acta Dermatovenerol Alp Pannonica Adriat. 2023 Dec;32(4):173-181.ABSTRACTThis review article focuses on cutaneous manifestations in schoolchildren and adolescents 6 to 18 years old connected with various aspects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, including personal protective equipment (PPE), SARS-CoV-2 infection, and the SARS-CoV-2 vaccine. The use of PPE has been associated with mask-related acne due to microbiome dysbiosis and disruption of skin homeostasis, leading to the emergence of new acne or exacerbation of preexisting acne. Chilblain-like lesions, erythema multiforme-lik...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Daniela Franuli ć Ena Para ć Lorena Dola čki Iva Topalu šić Liborija Lugovi ć-Mihić Source Type: research

A dermatological perspective: eosinophilic eruption of hematoproliferative disease as a clinical and histological dilemma
We present the case of a 70-year-old man with CLL in remission (previously treated with two 6-month cycles of fludarabine-cyclophosphamide plus rituximab, 2 and 5 years earlier) with an acute, disseminated polymorphic skin eruption. Skin biopsies from two sites (bulla and infiltrated nodule) were taken for histopathological examination. The pathologist reported giant spongiform vesicle formation with eosinophils with dermal and hypodermal inflammatory infiltrate composed of lymphocytes (predominantly T cells, fewer B cells) and eosinophils. Secondary neoplasm dissemination and sarcoidosis were excluded by means of immunohi...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Tijana Orlic Snezana Minic Emilija Manojlovic-Gacic Dubravka Zivanovic Igor Kapetanovic Source Type: research

Acute onset of leukemia cutis in a 70-year-old-patient: a case report
We report the case of a 70-year-old man with no significant medical history that presented with a rapid onset of generalized pink to livid papules. No enlarged lymph nodes were observed, and laboratory results revealed a low platelet count. A biopsy was performed, and histopathological examination revealed a cutaneous infiltration with a highly malignant blastoid neoplasm. Further examination performed by hematologists, including cytological analysis of a bone marrow puncture, confirmed acute myelogenous leukemia (AML). Molecular genetic testing revealed a mutation in the gene encoding nucleophosmin (NPM1), the most common...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Maru ša Selan Ne ža Stopajnik Source Type: research

Efficacy of alitretinoin in the treatment of Darier disease: a case report
We report the case of a female patient with Darier disease that was unsuccessfully treated with acitretin and isotretinoin but showed significant improvement with alitretinoin. Previous reports on the efficacy of alitretinoin in Darier disease are reviewed.PMID:38126103 (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Andreja Pagon Mateja Dolenc Volj č Source Type: research

Immunohistochemical expression of vitamin D receptor and Wnt signaling pathway molecules in psoriasis
CONCLUSION: Our findings confirm the significance of VDR signaling in the pathophysiology of psoriasis and strengthen the relationship between this disease and the Wnt signaling pathway. There was evidence that there is an association between VDR status and Wnt5a expression.PMID:38126094 (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Amina Ismaeel Fatima Alhashimi Zainab Almossali Safa Alshaikh Samvel Selvam Duha Janahi Source Type: research

Evaluation of corticophobia in patients with atopic dermatitis and psoriasis using the TOPICOP © score
CONCLUSIONS: The prevalence of corticophobia was comparable to that reported in other similar studies and was higher among female patients, which replicates previous findings. Patients with AD, who were younger on average than patients with PS, often relied on friends, acquaintances, family members, and the internet as their main information sources. Providing correct and reliable information to patients is crucial for ensuring treatment adherence.PMID:38126095 (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Mateja Starbek Zorko Maja Benko Mateja Raku ša Tanja Prunk Zdravkovi ć Source Type: research

Clinical and immunopathological characteristics of autoimmune blistering skin diseases
Acta Dermatovenerol Alp Pannonica Adriat. 2023 Dec;32(4):141-149.ABSTRACTAutoimmune blistering skin diseases (AIBDs) encompass several heterogeneous conditions clinically characterized by blisters and erosions on the skin and mucous membranes and are immunopathologically characterized by autoantibodies against structural proteins of the skin. Those proteins are responsible for the intercellular contact between epidermal keratinocytes and adhesion of the basal keratinocytes to the dermis. Therefore, AIBDs are divided into two main groups: intraepidermal (the pemphigus group) and subepidermal (the pemphigoid) groups. The dia...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Anita Gunari ć Dubravka Šimić Branka Marinovi ć Source Type: research

Recent advances in trichotillomania: a narrative review
Acta Dermatovenerol Alp Pannonica Adriat. 2023 Dec;32(4):151-157.ABSTRACTTrichotillomania, defined as the compulsive pulling out of one's hair, is a psychocutaneous condition associated with functional impairment and decreased quality of life. The pathophysiology of trichotillomania is poorly understood and likely multifactorial, involving alterations in both neural activity and cognitive function. Behavioral treatment options for trichotillomania are limited and are often only modestly effective. Moreover, there are no medications currently approved by the U.S. Food and Drug Administration for its treatment. The gaps in k...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Rachel E Christensen Isabella Tan Mohammad Jafferany Source Type: research

New anti-aging strategies: a narrative review
The objective of anti-aging medicine is to decelerate the aging process and mitigate its associated effects, such as susceptibility to cancer, diabetes, and cardiovascular and neurodegenerative diseases. This review provides an overview of the latest advancements in this field, considering both pharmaceutical and non-pharmaceutical approaches. Electronic literature search involved three databases: MEDLINE, Cochrane, and Google Scholar, supplemented by other available literature. Strategies for delaying aging and related diseases comprise pharmaceutical interventions and lifestyle choices. It is crucial for these strategies...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Vana Stoji ć Tea Štrbac Andrija Stanimirovi ć Source Type: research

Different skin wart types, different human papillomavirus types? A narrative review
Acta Dermatovenerol Alp Pannonica Adriat. 2023 Dec;32(4):165-171.ABSTRACTSkin warts are ubiquitous, self-limiting, benign neoplasms caused by human papillomaviruses (HPV). Several studies have investigated the prevalence and diversity of HPV types in the three main types of skin warts: common, plantar, and flat warts. Using different methodological approaches and diverse populations, several HPV types were detected in skin warts, but often the etiological link remained unconfirmed. This review addresses recently improved multiple strategies for investigating the presence of HPVs in skin warts, covering proper sampling tech...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Lucijan Skubic Vesna Breznik Mario Poljak Source Type: research

Cutaneous manifestations of the COVID-19 pandemic in schoolchildren and adolescents
Acta Dermatovenerol Alp Pannonica Adriat. 2023 Dec;32(4):173-181.ABSTRACTThis review article focuses on cutaneous manifestations in schoolchildren and adolescents 6 to 18 years old connected with various aspects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, including personal protective equipment (PPE), SARS-CoV-2 infection, and the SARS-CoV-2 vaccine. The use of PPE has been associated with mask-related acne due to microbiome dysbiosis and disruption of skin homeostasis, leading to the emergence of new acne or exacerbation of preexisting acne. Chilblain-like lesions, erythema multiforme-lik...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Daniela Franuli ć Ena Para ć Lorena Dola čki Iva Topalu šić Liborija Lugovi ć-Mihić Source Type: research

A dermatological perspective: eosinophilic eruption of hematoproliferative disease as a clinical and histological dilemma
We present the case of a 70-year-old man with CLL in remission (previously treated with two 6-month cycles of fludarabine-cyclophosphamide plus rituximab, 2 and 5 years earlier) with an acute, disseminated polymorphic skin eruption. Skin biopsies from two sites (bulla and infiltrated nodule) were taken for histopathological examination. The pathologist reported giant spongiform vesicle formation with eosinophils with dermal and hypodermal inflammatory infiltrate composed of lymphocytes (predominantly T cells, fewer B cells) and eosinophils. Secondary neoplasm dissemination and sarcoidosis were excluded by means of immunohi...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Tijana Orlic Snezana Minic Emilija Manojlovic-Gacic Dubravka Zivanovic Igor Kapetanovic Source Type: research