Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing

Although antigen cross-presentation is important for DCs to orchestrate anti-tumor CD8+ T  cell responses, the role of alternative antigen presentation pathways is unclear. MacNabb et al. show that CD8+ T cell priming can be mediated by DCs that acquire and present tumor-derived MHC-I complexes—a phenomenon known as MHC cross-dressing.

Source: Immunity - May 25, 2022 Category: Allergy & Immunology Authors: Brendan W. MacNabb, Sravya Tumuluru, Xiufen Chen, James Godfrey, Darshan N. Kasal, Jovian Yu, Marlieke L.M. Jongsma, Robbert M. Spaapen, Douglas E. Kline, Justin Kline Tags: Article Source Type: research