Crystal structures of cocrystals of 2,7-dihydroxynaphthalene with isoniazid and piracetam

Cocrystals of 2,7-dihydroxynaphthalene (DHN, or naphthalene-2,7-diol) with isoniazid (pyridine-4-carbohydrazide) (INH), denoted DHN – INH [C10H8O2 · C6H7N3O, (I)], and piracetam [2-(2-oxopyrrolidin-1-yl)acetamide] (PIR), denoted DHN – PIR [C10H8O2 · C6H10N2O2, (II)], were obtained by the solvent-assisted grinding method and characterized by IR spectroscopy, powder X-ray diffraction and single-crystal X-ray diffraction. Cocrystal (I) crystallized in the triclinic space group P\overline{1} and showed a 2:2 stoichiometry. DHN and INH molecules are connected by O — H...N(pyridine) and O — H...N(hydrazide) hydrogen bonds. Cocrystal (II) crystallized in the space group Pca21 with a 1:1 stoichiometry. DHN and PIR molecules are connected by O — H...O=C hydrogen bonds. The supramolecular architecture of cocrystal (I) showed interlinked supramolecular tapes; meanwhile, in cocrystal (II), interlinked supramolecular sheets were observed.

Source: Acta Crystallographica Section C - April 11, 2022 Category: Chemistry Authors: Gonz á lez-Gonz á lez, J.S. Valiente Flores, M.E. Flores-Alamo, M. L ó pez-Mac í as, E. Mart í nez-Mart í nez, F.J. Garc í a-Ortega, H. Tags: cocrystal piracetam isoniazid 2,7-dihydroxynaphthalene crystal structure IR spectroscopy API active pharmaceutical ingredient solvent-assisted grinding research papers Source Type: research