NDF is a transcription factor that stimulates elongation by RNA polymerase II [Research Communications]

RNA polymerase II (Pol II) elongation is a critical step in gene expression. Here we found that NDF, which was identified as a bilaterian nucleosome-destabilizing factor, is also a Pol II transcription factor that stimulates elongation with plain DNA templates in the absence of nucleosomes. NDF binds directly to Pol II and enhances elongation by a different mechanism than that used by transcription factor TFIIS. Moreover, yeast Pdp3, which is related to NDF, binds to Pol II and stimulates elongation. Thus, NDF is a Pol II binding transcription elongation factor that is localized over gene bodies and is conserved from yeast to humans.

Source: Genes and Development - March 22, 2022 Category: Genetics & Stem Cells Authors: Fei, J., Xu, J., Li, Z., Xu, K., Wang, D., Kassavetis, G. A., Kadonaga, J. T. Tags: Research Communications Source Type: research