Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T  cell clones

Using single-cell ECCITE-seq, Collora et  al. profiled 267 HIV-1 RNA+ cells and 68 expanded HIV-1 RNA+ T cell clones from 215,458 CD4+ T cells. HIV-1 resides in GZMB+ cytotoxic Th1 effector memory CD4+ T cell clones that are large and persistent. HIV-1-infected cytotoxic CD4+ T cells may evade cytotoxic CD8+ T cell killing through Se prin B9 degradation of granzyme B.

Source: Immunity - March 22, 2022 Category: Allergy & Immunology Authors: Jack A. Collora, Runxia Liu, Delia Pinto-Santini, Neal Ravindra, Carmela Ganoza, Javier R. Lama, Ricardo Alfaro, Jennifer Chiarella, Serena Spudich, Karam Mounzer, Pablo Tebas, Luis J. Montaner, David van Dijk, Ann Duerr, Ya-Chi Ho Tags: Article Source Type: research