Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity

Mucosal Immunology, Published online: 09 March 2022; doi:10.1038/s41385-022-00494-yGoblet cells through their production and secretion of mucins play an essential role in protecting the host against luminal insults, and contribute to the mutualism between host and gut microbiota. Loss of epithelial Gpr35 disrupts the goblet cell compartment by reducing their numbers and increasing pyroptosis levels. Dysregulation of goblet cells is correlated with changes in the mucosa-associated bacterial communities. As a result, Gpr35f/fVil+ mice displayed increased susceptibility to C. rodentium-induced colitis. (Adapted from SERVIER MEDICAL ART (CC of license 3.0)).

Source: Mucosal Immunology - March 9, 2022 Category: Allergy & Immunology Authors: Hassan Melhem Berna Kaya Tanay Kaymak Philipp Wuggenig Emilio Flint Julien Roux Koen C. Oost Claudia Cavelti-Weder Maria L. Balmer Jean-Claude Walser Rodrigo A. Morales Christian U. Riedel Prisca Liberali Eduardo J. Villablanca Jan Hendrik Niess Source Type: research