Variations in clot phenotype following injury: The MA-R ratio and fragile clots

CONCLUSIONS

MA-R identifies a trauma-induced coagulopathy phenotype characterized in blunt injury by impaired thrombin generation that is associated with early and late mortality. The endotheliopathy and tissue factor release likely plays a role in the cascade of impaired thrombin burst, possible early fibrinogen consumption and the weaker clot identified by MA-R.

LEVEL OF EVIDENCE

Therapeutic/care management, level II.

Source: Journal of Trauma and Acute Care Surgery - February 24, 2022 Category: Surgery Tags: 2021 WTA ORAL Source Type: research