Universal cell free DNA or contingent screening for trisomy 21 – does it make a difference? A comparative study with real data.

Objective: To compare the detection rate for trisomy 21 of universal cell free DNA (cfDNA) screening with contingent screening. Methods: Retrospective study at 3 German centers. The study included euploid and trisomy 21 pregnancies where cfDNA and first trimester (FT) screening assessment was carried out. The FT risk for trisomy 21 was computed based on combined screening and stratified into the following classes: high risk>1:10, intermediate risk 1:11 – 2,500, low risk
Source: Fetal Diagnosis and Therapy - Category: Perinatology & Neonatology Source Type: research