The regulation roles of Ca2+ in erythropoiesis: what have we learned?

Red blood cells (RBCs) are generated from hematopoietic stem and progenitor cells (HSPCs) through the step-wise process of differentiation known as erythropoiesis. According to the colony formation activity, two different erythroid progenitor cells have been functionally defined, namely early burst-forming unit erythroid cells (BFU-E) and late colony-forming unit erythroid cells (CFU-E) progenitor cells. The earliest morphologically identifiable erythroid precursor is the pro-erythroblast, which differentiates sequentially into the basophilic, poly-chromatophilic and orthochromatic erythroblast, and finally becomes reticulocytes after enucleation.

Source: Experimental Hematology - December 5, 2021 Category: Hematology Authors: Yuanzhen Zhang, Yan Xu, Shujing Zhang, Zhiyuan Lu, Yuan Li, Baobing Zhao Source Type: research