The scleromyositis phenotype. Lessons from a multicentre international cohort of anti-PM/Scl –positive patients

SSc and myositis are well-recognized neighbours, and in some cases the clinical features of the two disorders overlap, as occurs in patients with a unique antibody, anti-PM/Scl, in a condition known as scleromyositis. In addition, myositis and SSc patients can have a similar genetic background [1]. This may explain why some patients with antisynthetase syndrome —an overlap myositis syndrome characterized by coexistence of myositis, interstitial lung disease and arthritis—and antibodies against several t-RNA synthetases can resemble patients with scleromyositis, specifically those with anti-PM/Scl antibodies [2].
Source: Rheumatology - Category: Rheumatology Source Type: research