Hyaluronidase Availability in Emergency Rooms: A State-Wide Analysis

Hyaluronic acid filler injection is generally regarded a safe procedure. However, serious ischemic complications do exist, notably blindness and skin necrosis. Hyaluronidase is an enzymatic reversal agent for hyaluronic acid fillers; it is used to treat acute ischemic complications. Unfortunately, many barriers exist for injector sites to stock hyaluronidase, including price, short shelf-life, and complacency given the low incidence of ischemic complications. As a result, emergency rooms (ERs) are often expected to be a safety net in cases when injectors encounter an ischemic complication but have inadequate supplies of hyaluronidase to address complications.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Plastic and Maxillofacial Surgery Source Type: research

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BACKGROUND A long-held goal of vision therapy is to transfer information directly to the visual cortex of blind individuals, thereby restoring a rudimentary form of sight. However, no clinically available cortical visual prosthesis yet exists.METHODS We implanted an intracortical microelectrode array consisting of 96 electrodes in the visual cortex of a 57-year-old person with complete blindness for a 6-month period. We measured thresholds and the characteristics of the visual percepts elicited by intracortical microstimulation.RESULTS Implantation and subsequent explantation of intracortical microelectrodes were carried o...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Nature, Published online: 01 December 2021; doi:10.1038/d41586-021-03576-2Age-related macular degeneration is the leading cause of blindness in older adults, but techniques are being developed to offset the worst of the damage.
Source: Nature AOP - Category: Research Source Type: research
Gabriel García Valery Naranjo Glaucoma is a neurodegenerative disease process that leads to progressive damage of the optic nerve to produce visual impairment and blindness. Spectral-domain OCT technology enables peripapillary circular scans of the retina and the measurement of the thickness of the retinal nerve fiber layer (RNFL) for the assessment of the disease status or progression in glaucoma patients. This paper describes a new approach to segment and measure the retinal nerve fiber layer in peripapillary OCT images. The proposed method consists of two stages. In the first one, morphological operators ro...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Glaucoma is one of the most common causes of blindness, thus seriously affecting people’s health and quality of life. The topical medical therapy is as the first line treatment in the management of glaucoma since it is inexpensive, convenient, effective, and safe. This review summarizes and compares extensive clinical trials on the topical medications for the treatment of glaucoma, including topical monotherapy agents, topical fixed-combination agents, topical non-fixed combination agents, and their composition, mechanism of action, efficacy, and adverse effects, which will provide reference for optimal choice of cli...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Yuan Lei Despite of various therapeutic methods for treating ocular hypertension and glaucoma, it still remains the leading cause of irreversible blindness. Intraocular pressure (IOP) lowering is the most effective way to slow disease progression and prevent blindness. Among the ocular hypotensive drugs currently in use, only a couple act on the conventional outflow system, which is the main pathway for aqueous humor outflow and the major lesion site resulting in ocular hypertension. Nitric oxide (NO) is a commendable new class of glaucoma drugs that acts on the conventional outflow pathway. An increasing number of ni...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
In this study, we investigated the role of microRNA-124 (MiR-124) in surgically induced glaucomatous neurodegeneration using a mouse model. Animals were segregated into four cohorts of 10 each: (i) sham-operated (n = 10); (ii) surgically induced glaucoma (SIG; n = 10); (iii) SIG + miR-124 mimic; (iv) SIG + miR-NC. Chronic elevation of intraocular pressure (IOP) is a critical risk factor for glaucoma. In our study, chronically elevated IOP caused anterograde axonal transport (AAT) defect, increased the autophagic activity (manifested by significantly (p
Source: Cutaneous and Ocular Toxicology - Category: Toxicology Authors: Source Type: research
Undersea Hyperb Med. 2021 Fourth-Quarter;48(4):431-441.ABSTRACTDelayed neuropsychological sequelae (DNS) are relatively common complications of acute carbon monoxide (CO) poisoning, and usually develop within several days to weeks after the initial clinical recovery from acute CO poisoning. DNS can consist of various symptoms such as memory loss, confusion, ataxia, seizures, urinary incontinence, fecal incontinence, emotional lability, disorientation, hallucinations, mutism, cortical blindness, psychosis, parkinsonism, gait disturbances, rigidity, bradykinesia, and other motor disturbances. Paroxysmal sympathetic hyperacti...
Source: Undersea and Hyperbaric Medicine - Category: Sports Medicine Authors: Source Type: research
J Ophthalmic Vis Res. 2021 Oct 25;16(4):644-656. doi: 10.18502/jovr.v16i4.9755. eCollection 2021 Oct-Dec.ABSTRACTGlaucoma is a multifactorial disease and a leading cause of irreversible blindness worldwide. Current data has demonstrated the approximate distribution of primary open-angle glaucoma (POAG) in patients of European, African, Hispanic, and Eastern Asian descent. However, a significant gap in the literature exists regarding the prevalence of POAG in Middle Eastern (ME) populations. Current studies estimate ME POAG prevalence based on a European model. Herein we screened 65 total publications on ME prevalence of PO...
Source: Journal of Ophthalmic and Vision Research - Category: Opthalmology Authors: Source Type: research
PURPOSE: :Ocular trauma is one of the major preventable causes of ocular morbidity and blindness in children and young adults. Firework injuries account for 20% of ocular trauma. The purpose of this study was to describe the clinical profile and assess the...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Title: What Are the Different Types of Color Blindness?Category: Diseases and ConditionsCreated: 11/29/2021 12:00:00 AMLast Editorial Review: 11/29/2021 12:00:00 AM
Source: MedicineNet Eyesight General - Category: Opthalmology Source Type: news
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