Negative urgency exacerbates relapse to cocaine seeking after abstinence.

The mechanisms through which drug-cue induced negative affective states are involved in relapse have not been defined. We tested the hypothesis that in individuals having developed a dorsolateral striatum (DLS)-dependent cue-controlled cocaine seeking habit, the loss of the opportunity to enact the drug seeking response during abstinence results in an urge to act that exacerbates relapse severity mediated by negative urgency.

Source: Biological Psychiatry - October 19, 2021 Category: Psychiatry Authors: Maxime Fouyssac, Yolanda Pe ña-Oliver, Mickaёl Puaud, Nicole Lim, Chiara Giuliano, Barry J. Everitt, David Belin Tags: Archival Report Source Type: research