Troubling connections between epilepsy, health problems during childbirth
The risk of severe maternal morbidity — serious problems such as needing blood transfusions, hysterectomies or ventilators — are found to be steep, researchers say.
Expert Rev Med Devices. 2021 Nov 26. doi: 10.1080/17434440.2021.2012152. Online ahead of print.ABSTRACTINTRODUCTION: : Wearable electroencephalography (EEG) for objective seizure counting might transform the clinical management of epilepsy. Non-EEG modalities have been validated for the detection of convulsive seizures, but there is still an unmet need for the detection of non-convulsive seizures.AREAS COVERED: : The main objective of this systematic review was to explore the current status on wearable surface- and subcutaneous EEG for long-term seizure monitoring in epilepsy. We included 17 studies and evaluated the progr...
Dravet syndrome (DS) is a developmental and epileptic encephalopathy, characterized by epilepsy, cognitive decline, behavior disorders and motor impairment , caused by a mutation in SCN1A in almost all the patients. SCN1A encodes the α1 subunit of the voltage-gated sodium channel (Nav1.1) and its loss of function determines a dysfunction of GABAergic interneurons with consequent impairment of inhibitory pathways . The mortality in DS is very high, not only compared to healthy controls but also to other patients with drug-res istant epilepsy, who are about three times less likely to die .
Therapeutic drug monitoring (TDM) of older generation antiseizure medications (ASMs) such as phenytoin, carbamazepine, phenobarbital or valproate has been widely used since 1960 and the relationship between plasma ASM levels and a clinical effect was well established for some of these agents . Pharmacokinetic characteristics such as non-linear metabolism or drug-drug interactions support the use of TDM for this type of medication. Prescription of older agents however, is decreasing in favor of newer generation ASMs (i.e.
Epilepsy is a chronic condition characterised by risk of unprovoked seizures, which has multifaceted implications for the lives of individuals. People with epilepsy (PWE) experience related cognitive, emotional and psychological difficulties, including anxiety, depression and low self-esteem, as well as problems with family functioning. PWE also experience social and legal restrictions with possible implications for their welfare, not least in relation to driving and employment.
In this study, we evaluated the relationship between trough free VPA serum levels and concomitant platelet counts and assessed risk factors for the development of thrombocytopenia with the aim of generating a formula specifying the probabilities of developing thrombocytopenia based on trough free serum VPA levels.
: The COVID-19 pandemic has increased mortality worldwide and those with chronic conditions may have been disproportionally affected. However, it is unknown whether the pandemic has changed mortality rates for people with epilepsy. We aimed to compare mortality rates in people with epilepsy in Wales during the pandemic with pre-pandemic rates.
People with epilepsy face serious driving restrictions, determined using retrospective studies. To relate seizure characteristics to driving impairment, we aimed to study driving behavior during seizures with a simulator. Patients in the Yale New Haven Hos...
CONCLUSION: High-quality evidence in the form of randomized controlled trials to guide clinicians in choosing an AED in patients with dementia and concomitant epilepsy remains scarce. However, levetiracetam has previously been shown to possibly improve cognition in patients with both mild cognitive impairment and Alzheimer's disease, is better tolerated in the elderly population, and has no clinically relevant interaction with either cholinesterase inhibitors or NMDA receptor antagon- ists.PMID:34825872 | DOI:10.2174/1567205018666211126121529
Conclusions: Highly synchronized ictal ECoG discharges with high amplitude of greater than 1500 to 2000 μV in the medial temporal lobe could be recorded on the scalp as ictal EEG discharges via volume conduction.PMID:34825584 | DOI:10.1177/15500594211062702