New dimeric phloroglucinol derivatives from Agrimonia pilosa and their hepatoprotective activities

Bioorg Chem. 2021 Sep 8;116:105341. doi: 10.1016/j.bioorg.2021.105341. Online ahead of print.ABSTRACTFive new dimeric phloroglucinol derivatives, agrimones A - E (1-5), were isolated from the whole plant of Agrimonia pilosa. Their structures including absolute configurations were determined by a series of spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR), complemented with the comparison of the experimental and calculated ECD spectra, and gauge-independent atomic orbital (GIAO) NMR calculations. Notably, compounds 1 and 2 represent a highly oxidized 6/6/6 tricyclic ring skeleton based on the cis-fused paraquinone and chroman. Compounds 1a, 4, and 5 exhibited moderate hepatoprotective activities against APAP-induced HepG2 cell injury at 10 μM.PMID:34525394 | DOI:10.1016/j.bioorg.2021.105341

Source: Bioorganic Chemistry - September 15, 2021 Category: Chemistry Authors: Jia Zhang Ya-Nan Yang Jian-Shuang Jiang Zi-Ming Feng Xiang Yuan Xu Zhang Pei-Cheng Zhang Source Type: research