A high fraction of inspired oxygen may increase mortality in intubated trauma patients – A retrospective cohort study

Tracheal intubation and mechanical ventilation of trauma patients may be life-saving interventions, as many trauma patients are unable to protect their airway and require an increased fraction of inspired oxygen (FiO2) to avoid hypoxaemia. However, exposure to a high FiO2 carries a risk of hyperoxia, which has been associated with an increased production of reactive oxygen species, cerebral and coronary vasoconstriction, deleterious effects on lung function, and mortality. [1 –5]

Source: Injury - September 17, 2021 Category: Orthopaedics Authors: Josefine S. Baekgaard, Volkert Siersma, Rasmus Ejlersgaard Christensen, Camilla Ikast Ottosen, Katrine  Bennett Gyldenkærne, Jasmin Garoussian, Emilie S. Baekgaard, Jacob Steinmetz, Lars S. Rasmussen Source Type: research