Knockout of {alpha}A-Crystallin Inhibits Ocular Neovascularization [Retina]

Conclusions.
Knockout of αA-crystallin inhibited pathologic neovascularization through the VEGF and VEGFR2 signaling pathways both in vitro and in vivo. These results suggest that αA-crystallin could be a novel pharmaceutical target for the prevention of ocular neovascularization.

Source: Investigative Ophthalmology - February 5, 2015 Category: Opthalmology Authors: Xu, Q., Bai, Y., Huang, L., Zhou, P., Yu, W., Zhao, M. Tags: Retina Source Type: research