A disposable, wearable, flexible, stitched textile electrochemical biosensing platform

Biosens Bioelectron. 2021 Sep 1;194:113604. doi: 10.1016/j.bios.2021.113604. Online ahead of print.ABSTRACTWearable sensors are a fast growing and exciting research area, the success of smart watches are a great example of the utility and demand for wearable sensing systems. The current state of the art routinely uses expensive and bulky equipment designed for long term use. There is a need for cheap and disposable wearable sensors to make single use measurements, primarily in the area of biomarker detection. Herein we report the ability to make cheap (0.22 USD/sensor), disposable, wearable sensors by stitching conductive gold coated threads into fabrics. These threads are easily functionalised with thiolate self-assembled monolayers which can be designed for the detection of a broad range of different biomarkers. This all textile sensing platform is ideally suited to be scaled up and has the added advantage of being stretchable with insignificant effect on the electrochemistry of the devices. As a proof of principle, the devices have been functionalised with a continuous glucose sensing system which was able to detect glucose in human sweat across the clinically relevant range (0.1-0.6 mM). The sensors have a sensitivity of 126 ± 14 nA/mM of glucose and a limit of detection of 301 ± 2 nM. This makes them ideally suited for biomarker detection in point-of-care sensing applications.PMID:34488171 | DOI:10.1016/j.bios.2021.113604

Source: Biosensors and Bioelectronics - September 6, 2021 Category: Biotechnology Authors: Andrew Piper Ingrid Öberg Månsson Shirin Khaliliazar Roman Landin Mahiar Max Hamedi Source Type: research