Prime Therapeutics rises to Minnesota's No. 2 largest private company as pharmacy costs rise

CEO Ken Paulus said the company ’s steady growth has largely been driven by increases in pharmacy spending, specifically for prescription medications used to treat complex conditions including oncology, autoimmune and rare diseases.
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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SummaryInflammatory neuropathies are a heterogeneous group of rare diseases of the peripheral nervous system that include acute and chronic diseases, such as Guillain-Barr é syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The etiology and pathophysiological mechanisms of inflammatory neuropathies are only partly known, but are considered autoimmune disorders in which an aberrant immune response, including cellular and humoral comp onents, is directed towards components of the peripheral nerve causing demyelination and axonal damage. Therapy of these disorders includes broad-spect...
Source: Neurotherapeutics - Category: Neurology Source Type: research
Discussion Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory disease with a strong autoimmune association. It can occur with other autoimmune diseases. Its specific cause is unknown. It affects females and males of all ages, but especially females 40-60 years. In the pediatric population it affects prepubertal females most often. Treatment includes steroid medications or anti-inflammatory medications. Other treatments may be offered including phototherapy, and much less commonly systemic steroids or immunosuppressive therapy. Circumcision may also be an option for some males. Childhood LSA generally improves b...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
CEO Ken Paulus said the company ’s steady growth has largely been driven by increases in pharmacy spending, specifically for prescription medications used to treat complex conditions including oncology, autoimmune and rare diseases.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Regardless of immunosuppressant use, physicians should be aware of pulmonary and extra-pulmonary tuberculosis in patients with autoimmune disease including systemic sclerosis, especially if they follow unusual clinical courses. AbstractRegardless of immunosuppressant use, physicians should be aware of pulmonary and extra-pulmonary tuberculosis in patients with autoimmune disease including systemic sclerosis, especially if they follow unusual clinical courses.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CLINICAL IMAGE Source Type: research
Conditions:   SARS-CoV2 Infection;   Rare Diseases;   Chronic Inflammatory Rheumatism;   Autoimmune Diseases Intervention:   Other: no intervention Sponsors:   Assistance Publique - Hôpitaux de Paris;   FAI²R (Auto-immune and auto-inflammatory rare diseases French network) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Primary adrenal insufficiency (PAI) is a rare disease and potentially fatal if unrecognized. It is characterized by destruction of the adrenal cortex, most frequently of autoimmune origin, resulting in glucocorticoid, mineralocorticoid, and adrenal androgen deficiencies. Initial signs and symptoms can be nonspecific, contributing to late diagnosis. Loss of zona glomerulosa function may precede zona fasciculata and reticularis deficiencies. Patients present with hallmark manifestations including fatigue, weight loss, abdominal pain, melanoderma, hypotension, salt craving, hyponatremia, hyperkalemia, or acute adrenal crisis....
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
We report a case with characteristic symptoms of limbic encephalitis associated with combined small cell lung carcinoma. The brain magnetic resonance imaging showed bilateral temporal lesions and the photoemission tomography revealed regional heterogenous metabolism across the brain. The double labeling of anti-gamma-aminobutyric acid-B receptor autoantibodies both in the tissues of neuroendocrine and small cell neoplasia was a unique feature of this patient.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Tags: Short Communication Source Type: research
We report the data in the literature on this topic and a case of pemphigus-associated autoimmune myocarditis with damage of intercalated disc responding to immunosuppressive therapy. The occurrence of cardiomyopathy with left ventricular dysfunction in patients affected by pemphigus should be appropriately screened with endomyocardial biopsy as it could be the myocardial extension of a potentially reversible autoimmune disorder.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Review Source Type: research
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