Houston health tech firm Saranas raises $12.8M Series B

Houston-based medical device company Saranas Inc. closed a $12.8 million Series B funding round, the firm announced July 19. The Series B round was led by Chicago-based Baird Capital, the venture capital and private equity arm of Milwaukee-based Robert W. Baird&Co. The round also saw participation from Austin-based S3 Ventures. The Houston-based company develops an FDA-approved medical device for early detection and monitoring of internal bleeding complications. Saranas' Early Bird device aims…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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CONCLUSIONS: Currently, available evidence does not unequivocally support the clinical effectiveness of andexanet alfa or prothrombin complex concentrate to reverse factor Xa inhibitor-associated acute major bleeding, nor does it permit conventional meta-analysis of potential superiority. Neither reversal agent was significantly associated with increased effectiveness or a higher rate of venous thromboembolic event. These results underscore the importance of randomized controlled trials comparing the two reversal agents and may provide guidance in designing institutional guidelines.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Review Article Source Type: research
Yiwen Xu Video coding technology makes the required storage and transmission bandwidth of video services decrease by reducing the bitrate of the video stream. However, the compressed video signals may involve perceivable information loss, especially when the video is overcompressed. In such cases, the viewers can observe visually annoying artifacts, namely, Perceivable Encoding Artifacts (PEAs), which degrade their perceived video quality. To monitor and measure these PEAs (including blurring, blocking, ringing and color bleeding), we propose an objective video quality metric named Saliency-Aware Artifact Measuremen...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
We describe the stepwise management of anticoagulation in a coagulopathic patient with persistent cardiogenic shock following a coronary artery bypass procedure who underwent Impella 5.5 placement. A direct thrombin inhibitor-based purge solution was utilized while evaluating for heparin-induced thrombocytopenia. The use of a novel bicarbonate-based purge solution (BBPS) was successfully used due to severe coagulopathy. There were no episodes of pump thrombosis or episodes of severe bleeding on the BBPS and systemic effects of alkalosis and hypernatremia were minimal.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
CONCLUSION: Although laparoscopic visualization had relatively high sensitivity and positive predictive value, its specificity and negative predictive value were relatively low. These findings support the use of laparoscopic visualization with histopathological analysis for accurate diagnosis of endometriosis.PMID:34562632 | DOI:10.1016/j.jogc.2021.08.013
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Authors: Source Type: research
Approximately 1 in 4 women with menorrhagia and dysmenorrhea have clinical evidence of adenomyosis. For those who have completed childbearing, hysterectomy provides definitive symptom management. Several medical options, including combined oral contraceptives, GnRH agonist/antagonist, and antiandrogens, can be used if future fertility is desired. The levonorgestrel-releasing intrauterine device (LNG-IUD) is a highly effective alternative, with evidence suggesting reductions in pain, bleeding, and even uterine volumes among women with adenomyosis (1).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
In this issue of JMIG, we highlight a pilot study of primary hysteroscopic management of early miscarriage. Historically, patients have been offered a dilation and curettage (D&C) as the only surgical treatment option for miscarriage. Typically done without ultrasound guidance, D&Cs may be associated with complications including bleeding, infection, and perforation.1 –3 Importantly, D&Cs can disrupt the basalis layer of the endometrium leading to increased risk of intrauterine adhesions and subsequent hypofertility.1 Risk of intrauterine adhesions after miscarriage have been reported as high as 40% and may be increas...
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: EDITORIAL Source Type: research
Approximately 1 in 5 patients undergo noncardiac surgery within the first year after a drug-eluting stent (DES) implantation.1 –3 For these patients, it is recommended that a multidisciplinary team, including cardiologists and surgeons, evaluates the indication for and timing of the surgery and the consequences of interrupting dual antiplatelet therapy (DAPT). Such consequences include an increased risk of thrombotic even ts such as stent thrombosis and risk of bleeding associated with surgery.4,5 Based on 2 recent cohort studies,3,6 the 2018 European Society of Cardiology DAPT consensus document suggested that when ...
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Acute variceal bleeding is a complication of portal hypertension, usually due to cirrhosis, with high morbidity and mortality. There are 3 scenarios for endoscopic treatment of esophageal varices: prevention of first variceal bleed, treatment of active variceal bleed, and prevention of rebleeding. Patients with cirrhosis should be screened for esophageal varices. Recommended endoscopic therapy for acute variceal bleeding is endoscopic variceal banding. Although banding is the first-choice treatment, sclerotherapy may have a role. Treatment with Sengstaken-Blakemore tube or self-expanding covered metallic esophageal stent c...
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
Circ J. 2021 Sep 23. doi: 10.1253/circj.CJ-21-0751. Online ahead of print.ABSTRACTOptimal antiplatelet therapy after percutaneous coronary intervention (PCI) has been changed in parallel with the improvements of coronary stent and antiplatelet therapy. Over the past 25 years, dual antiplatelet therapy (DAPT) with aspirin plus P2Y12inhibitor has been the standard of care used after coronary stent implantation. First-generation drug-eluting stent (DES) appeared to increase the risk of late stent thrombosis, and duration of DAPT was prolonged to 12 months. DAPT duration up to 12 months was the dominant strategy after DES impl...
Source: Circulation Journal - Category: Cardiology Authors: Source Type: research
This study describes a single-center experience treating submassive PE with CDT while utilizing repeat angiography to determine treatment efficacy.METHODS: A retrospective analysis of 140 consecutive patients who underwent CDT for submassive PE from December 2012 to June 2019 was performed. Angiographic resolution of thrombus burden after CDT was reported as high (>75%), moderate (51-75%), low (26-50%), or insignificant (≤25%). All angiograms were reviewed by two interventional radiologists. Secondary endpoints included reduction in pulmonary artery pressure (PAP) and clinical outcomes. Bleeding events were classifie...
Source: Diagnostic and Interventional Radiology - Category: Radiology Authors: Source Type: research
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