Zydus Cadila gets tentative USFDA nod to market generic sclerosis treatment drug

Drug firm Zydus Cadila on Thursday said it has received tentative approval from the US health regulator to market Fingolimod capsules, used in the treatment of multiple sclerosis, in the American market.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news

Related Links:

Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
J Immunol. 2021 Sep 24:ji2001261. doi: 10.4049/jimmunol.2001261. Online ahead of print.ABSTRACTSystemic suppression of adaptive immune responses is a major way in which UV radiation contributes to skin cancer development. Immune suppression is also likely to explain how UV protects from some autoimmune diseases, such as multiple sclerosis. However, the mechanisms underlying UV-mediated systemic immune suppression are not well understood. Exposure of C57BL/6 mice to doses of UV known to suppress systemic autoimmunity led to the accumulation of cells within the skin-draining lymph nodes and away from non-skin-draining lymph ...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research
INTRODUCTION: There is growing evidence on the efficacy of gait robotic rehabilitation in patients with multiple sclerosis (MS), but most of the studies have focused on gait parameters. Moreover, clear indications on the clinical use of robotics still lack...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news
Ann Agric Environ Med. 2021 Sep 16;28(3):372-377. doi: 10.26444/aaem/127062. Epub 2020 Sep 17.ABSTRACTINTRODUCTION: Multiple sclerosis (MS) is a disease of unknown etiology. Diagnosis of MS is primarily based on detection of myelin damage by magnetic resonance imaging (MRI) and classification of demyelination according to the McDonald Criteria. Cholecalciferol (vitamin D3) has been shown to affect the onset and progression of MS via its immunomodulating properties. The role of vitamin D in MS pathogenesis and treatment deserves further investigation, as there is sufficient evidence to suggest a correlation between vitamin ...
Source: Annals of Agricultural and Environmental Medicine : AAEM - Category: Environmental Health Authors: Source Type: research
Methods Mol Biol. 2022;2389:57-66. doi: 10.1007/978-1-0716-1783-0_5.ABSTRACTNSCs have been demonstrated to be very useful in grafts into the mammalian central nervous system to investigate the exploitation of NSC for the therapy of neurodegenerative disorders in animal models of neurodegenerative diseases. To push cell therapy in CNS on stage of clinical application, it is necessary to establish a continuous and standardized, clinical grade (i.e., produced following the good manufacturing practice guidelines) human neural stem cell lines.In this chapter we will illustrate some of the protocols for the production and charac...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Source Type: research
Immunology. 2021 Sep 24. doi: 10.1111/imm.13420. Online ahead of print.ABSTRACTAutoimamune disease is an inappropriate response to one's tissues due to a break in immune tolerance and exposure to self-antigens. It often leads to structural and functional damage to organs as well as systemic disorders. To date, there are no effective interventions to prevent the progression of autoimmune diseases. Hence, there is an urgent need for new treatment targets. TRPM7 is an enzyme-coupled, transient receptor ion channel of the subfamily M that plays a vital role in pathologic and physiologic conditions. While TRPM7 is constitutivel...
Source: Immunology - Category: Allergy & Immunology Authors: Source Type: research
Ann Agric Environ Med. 2021 Sep 16;28(3):372-377. doi: 10.26444/aaem/127062. Epub 2020 Sep 17.ABSTRACTINTRODUCTION: Multiple sclerosis (MS) is a disease of unknown etiology. Diagnosis of MS is primarily based on detection of myelin damage by magnetic resonance imaging (MRI) and classification of demyelination according to the McDonald Criteria. Cholecalciferol (vitamin D3) has been shown to affect the onset and progression of MS via its immunomodulating properties. The role of vitamin D in MS pathogenesis and treatment deserves further investigation, as there is sufficient evidence to suggest a correlation between vitamin ...
Source: Annals of Agricultural and Environmental Medicine : AAEM - Category: Environmental Health Authors: Source Type: research
Dr Stephen Krieger on how effective vaccines are in these patients, who should receive boosters, and when.Medscape Neurology
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery Commentary Source Type: news
Condition:   Multiple Sclerosis Interventions:   Drug: IMU-838;   Drug: Placebo matching IMU-838 Sponsor:   Immunic AG Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This review hypothesizes that the neurologist represents the linchpin of exercise behavior change within comprehensive multiple sclerosis (MS) care settings. This is based on a series of recent articles that developed actionable practice models for accomplishing such behavior change through the neurologist as the primary agent. This provides tangible, next steps for exercise promotion in MS.
Source: Exercise and Sport Sciences Reviews - Category: Sports Medicine Tags: Articles Source Type: research
More News: Biotechnology | Gilenya | Multiple Sclerosis | Pharmaceuticals