Novel Advances in Biotransformation and Bioactivation Research - 2020 year in review

Drug Metab Rev. 2021 Apr 28:1-91. doi: 10.1080/03602532.2021.1916028. Online ahead of print.ABSTRACTThis annual review is the sixth of its kind since 2016 (see references). Our objective is to explore and share articles which we deem influential and significant in the field of biotransformation and bioactivation. These fields are constantly evolving with new molecular structures and discoveries of corresponding pathways for metabolism that impact relevant drug development with respect to efficacy and safety. Based on the selected articles, we created three sections: (1) drug design, (2) metabolites and drug metabolizing enzymes, and (3) bioactivation and safety (Table 1). Unlike in years past, more biotransformation experts have joined and contributed to this effort while striving to maintain a balance of authors from academic and industry settings.PMID:33910427 | DOI:10.1080/03602532.2021.1916028

Source: Drug Metabolism Reviews - April 29, 2021 Category: Drugs & Pharmacology Authors: S Cyrus Khojasteh Upendra A Argikar James P Driscoll Carley J S Heck Lloyd King Klarissa D Jackson Wenying Jian Amit S Kalgutkar Grover P Miller Valerie Kramlinger Ivonne M C M Rietjens Aaron M Teitelbaum Kai Wang Cong Wei Source Type: research