The utility of Vibratip in accurate identification of loss of protective sensation in the contralateral foot of patients admitted with a diabetic foot ulcer
Publication date: May–June 2021Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 15, Issue 3Author(s): Elaina Pasangha, Belinda George, V. Jayalakshmi, Padmini Devi, Vageesh Ayyar, Ganapathi Bantwal
Peripheral neuropathy is one of the most common neurologic conditions of late adulthood. Over 5% of those older than 55 years of age and over 30% of those older than 80 have probable or definite neuropathy.1 Neuropathy is a major cause of morbidity and reduced quality of life (QOL) due to pain, gait disturbance, foot ulceration, and amputation, particularly among diabetic patients. Up to half of patients with neuropathy have diabetes, and about 40% have idiopathic neuropathy. A number of studies suggest that prediabetes and metabolic syndrome are risk factors for idiopathic neuropathy,2-4 although there are conflicting data.
Publication date: Available online 21 May 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Sumarno Adi Subrata, Rutja Phuphaibul, Margaret Grey, Apinya Siripitayakunkit, Noppawan Piaseu
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Conclusions: The LSG is an effective method of treatment in all areas of metabolic syndrome, provides a significant positive clinical outcome in obesity-related comorbidities and induces desirable changes in inflammatory, kidney and liver related biomarkers. PMID: 32117497 [PubMed]
ConclusionThere was an increase in the prevalence of neuroischemic DFU. The Enterobacteriaceae family replaced SA as the most prevalent pathogen in DFI, with an increase in the isolation of gram-negative microorganisms and mixed polymicrobial cultures. Chronic neuroischemic infected ulcers usually present distinct bacterial isolates; knowledge about the most common agents is warranted in order to better select empiric antibiotic therapy.
We describe such lesions in a 62-year-old Muslim patient with uncontrolled glycemia who practiced prolonged, repeated religious prayers in sitting position causing significant pressure over dorsum of both ankles. He developed prayer-induced callous formation on dorsum of both ankles, with more thickening and a healed ulcer on left. Prayer-induced skin lesions should be carefully managed in patients with diabetes, who are more vulnerable for infections and gangrene due to as venous/arterial insufficiency and peripheral neuropathy.