Can biomarkers guide oncolytic virus immunotherapy?

Clin Cancer Res. 2021 Apr 13:clincanres.0660.2021. doi: 10.1158/1078-0432.CCR-21-0660. Online ahead of print.ABSTRACTDefects in tumor cell interferon-γ signaling is associated with resistance to immune checkpoint inhibitors. Recently, these defects were found to confer increased sensitivity to oncolytic virus infection. Differential expression of innate sensing elements in tumor cells may serve as predictive biomarkers of oncolytic virus immunotherapy in patients with cancer.PMID:33849964 | DOI:10.1158/1078-0432.CCR-21-0660
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Source Type: research