The Colonic Mucosal MicroRNAs, MicroRNA-219a-5p and MicroRNA-338-3p, are Downregulated in Irritable Bowel Syndrome and are Associated with Barrier Function and MAPK signaling

Alterations in microRNA (miRNA) and in the intestinal barrier are putative risk factors for irritable bowel syndrome (IBS). We aimed to identify differentially expressed colonic mucosal miRNAs, their targets in IBS compared to healthy controls (HCs), and putative downstream pathways.

Source: Gastroenterology - February 19, 2021 Category: Gastroenterology Authors: Swapna Mahurkar-Joshi, Carl Robert Rankin, Elizabeth Jane Videlock, Artin Soroosh, Abhishek Verma, Ariela Khandadash, Dimitrios Iliopoulos, Charalabos Pothoulakis, Emeran A. Mayer, Lin Chang Source Type: research