miR-100 alleviates the inflammatory damage and apoptosis of H2O2-induced human umbilical vein endothelial cells via inactivation of Notch signaling by targeting MMP9.

CONCLUSIONS: Our study demonstrated that miR-100 reduced the inflammatory damage and apoptosis of H2O2-induced human umbilical vein endothelial cells via inactivation of Notch signaling by targeting matrix metalloproteinase. These findings suggested that miR-100 might be a novel therapeutic target for the prevention of thromboangiitis obliterans.
PMID: 33530884 [PubMed - as supplied by publisher]

Source: Vascular - February 2, 2021 Category: Surgery Authors: Wang C, Zhang Y, Jiang Z, Bai H, Du Z Tags: Vascular Source Type: research