Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways

Preeclampsia evolves in 2 stages: a placental problem that generates signals to the mother to cause a range of responses that comprise the second stage (preeclampsia syndrome). The first stage of early-onset preeclampsia is poor placentation, which we here call malplacentation. The spiral arteries are incompletely remodeled, leading to later placental malperfusion, relatively early in the second half of pregnancy. The long duration of the first stage (several months) is unsurprisingly associated with fetal growth restriction.

Source: American Journal of Obstetrics and Gynecology - February 2, 2021 Category: OBGYN Authors: Christopher W.G. Redman, Anne Cathrine Staff, James M. Roberts Tags: Expert Review Source Type: research