Regiodivergent Synthesis of Spirocyclic Compounds through Pd-Catalyzed Regio- and Enantioselective [3+2] Spiroannulation.

Regiodivergent Synthesis of Spirocyclic Compounds through Pd-Catalyzed Regio- and Enantioselective [3+2] Spiroannulation.
Angew Chem Int Ed Engl. 2021 Jan 20;:
Authors: Trost BM, Zuo Z
Abstract
A novel Pd(0)-catalyzed highly regio- and enantioselective  [3+2] spiroannulation reaction has been developed for rapid assembly of a new class of [5,5] spirocyclic carbo- and heterocycles. Notably, the regioselectivity could be dominated by fine-tuning of the Pd-𝝅-allyl intermediate. An array of coupling partners could be well-tolerated with excellent regio-, and enantioselectivtities. Moreover, the potential application of this reaction was exemplified by several further transformations.
PMID: 33474803 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - January 20, 2021 Category: Chemistry Authors: Trost BM, Zuo Z Tags: Angew Chem Int Ed Engl Source Type: research