ALK3 Is Not Required for the Embryonic Development, Homeostasis, and Repopulation of Epidermal Langerhans Cells in Steady and Inflammatory States

Epidermal Langerhans cells (LCs) are skin-resident dendritic cells, although recently LCs were also classified as specialized macrophages on the basis of their embryonic development shared with tissue-resident macrophages (Doebel et  al., 2017; Hoeffel et al., 2012). LCs maintain skin immune surveillance and are involved in skin disorders, including psoriasis (Eidsmo and Martini, 2018; Kaplan, 2017). Adult LCs homeostasis is maintained throughout lifetime self-renewal at steady state, but the impaired LCs could arise by bone marrow–derived precursors at inflammatory state (Ginhoux et al., 2006; Seré et al., 2012).

Source: Journal of Investigative Dermatology - December 22, 2020 Category: Dermatology Authors: Qian Yu, Nirmal Parajuli, Qijun Yi, Yuji Mishina, James T. Elder, Li Zhou, Qing-Sheng Mi Tags: Letters to the Editor Source Type: research