Cipla recalls over 5.8 lakh packets of gastric ulcer treatment drug in US

The drug major is recalling esomeprazole magnesium for delayed-release oral suspension in unit dose packets in strengths 10 mg, 20 mg and 40 mg in the US market, the latest Enforcement Report by the USFDA said.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news

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ConclusionClipping, injection, and/or coagulation therapy can lead to high success rates for hemostasis, considering the anatomical characteristics in a pediatric population.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
Authors: Liu LN, Wang L, Jia SJ, Wang P Abstract BACKGROUND The aims of this study were to summarize the clinical characteristics and risk factors for bezoars and to analyze the effectiveness and safety of the endoscopic treatment of bezoars. MATERIAL AND METHODS From January 2015 to February 2020, 75 of the 23 950 patients who underwent gastroscopic examination in our medical center were diagnosed with bezoars. Clinical and treatment information for these patients was collected retrospectively and analyzed. RESULTS The detection rate of bezoars was 0.31%. Risk factors included the time of year (autumn and winter s...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Foreign body ingestion is a common clinical problem. The upper esophagus is the most common site of foreign body, accounting for more than 75% of all cases, but cases with a foreign body in the duodenal papill...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Case report Source Type: research
There is currently no consensus on the preferred treatment strategy for perforated gastric ulcer. Our study aims to compare the surgical outcomes following gastric resection vs omental patch by performing systematic review and meta-analysis.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: General Surgery Source Type: research
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.0c00424
Source: ACS Chemical Neuroscience - Category: Neuroscience Authors: Source Type: research
Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small intestine. NSAID-induced gastric ulcers can be prevented by taking acid-neutralizing/inhibitory drugs and cytoprotective agents. In contrast, there are no medicines to control NSAID-induced small intestinal ulcers, which are accompanied by a mucosal invasion of bacteria and subsequent activation of immune cells. Galectin-3 (Gal3), an endogenous lectin, has anti-microbial and pro-inflammatory functions. In the small intestine, since Gal3 is highly expressed in epithelial cells constitutively and macrop...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion Oral ulcers are common problems seen by dentists but pediatricians also see them. Usually families have are concerned because they are painful and acute. Ulcers are sometime noticed by the physician and not the family as in the case of herpangina or hand-foot and mouth disease. Chronic or recurrent ulcerations present less commonly and therefore it may be more difficult to determine their etiology. Many of the systemic disease causes of oral ulcers are overall infrequent and/or not common in the pediatric age range. Ulcers can be classified in several ways but acute ulcers are usually painful and last less tha...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Abstract Gastric ulcer is a frequent gastrointestinal tract (GIT) disorder that affects about 10% of the world population. Drug candidates that can provide high efficacy and low toxicity are needed value for the prevention and treatment of gastric ulcers. The present study aimed to assess the protective effect of mesalazine against ethanol-induced gastric mucosal injury in rats. The rats were divided into five groups, normal, ethanolic, standard (recipient ranitidine 50 mg/kg), experimental groups 1, 2 (receive mesalazine at doses of 50 and 100, respectively). The protective effect of mesalazine was evaluated by...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
Abstract Gastric ulcer is a prevalent disease with various etiologies, including non-steroidal anti-inflammatory drugs (NSAIDs), stress conditions, and alcohol, resulting in an inflammatory condition in the gastric mucosa. The aim of this study was to explore the protective effects of modafinil on gastric erosions induced by indomethacin, water-immersion stress, and alcohol in rats and to evaluate the role of nitric oxide (NO) pathway. Animals were allocated to the three experimental models of gastric ulcer - indomethacin (30 mg/kg PO), water-immersion stress, and ethanol (5 ml/kg PO). Induction of gastric ulc...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
The objectives of our study were to determine the different metabolites in the Cyperus conglomeratus Rottb. methanol extract, and to assess its in vivo gastroprotective effect in ethanol-induced gastric ulcer model in rats. Serum levels of galactin-3 and TNF-α were employed as biochemical markers. To pinpoint for active agents, comprehensive metabolites profiling of extract via UPLC-qTOF-MS/MS was employed. A total of 77 chromatographic peaks were detected, of which 70 were annotated. The detected metabolites were categorized into phenolic acids and their derivatives, flavonoids, stilbenes, aurones, quinones, ter...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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