Knock-Down of SDR9C7 Impairs Epidermal Barrier Function

The Mendelian Disorders of Cornification consist of a highly heterogeneous group of disorders, and the majority of non-syndromic cases belong to the family of autosomal recessive congenital ichthyosis (ARCI). Mutations in SDR9C7 have been associated with ACRI, and clinical manifestations include mild to moderately dry, scaly skin with or without hyperkeratosis, palmoplantar keratoderma, and erythroderma. SDR9C7, with short-chain dehydrogenase/reductase activity, is known as NAD- or NADP-dependent oxidoreductase, and has been shown to be involved in the final step of epidermal lipid barrier formation by covalent binding of acylCer to the cornified envelope.

Source: Journal of Investigative Dermatology - January 7, 2021 Category: Dermatology Authors: Leila Youssefian, Fatemeh Niaziorimi, Amir Hossein Saeidian, Andrew South, Farzaneh Khosravi-bachehmir, Sadegh Khodavaisy, Hassan Vahidnezhad, Jouni Uitto Tags: Original Article Source Type: research