"World Alzheimer Report 2014"

Released today from Alzheimer's Disease International (ADI):World Alzheimer Report 2014Access the report here
Source: BrainBlog - Category: Neurologists Source Type: blogs

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Source: Neurology Today - Category: Neurology Tags: In the Pipeline Source Type: research
Publication date: Available online 21 January 2020Source: Journal of Molecular BiologyAuthor(s): Shinya Honda, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Hajime Tajima-Sakurai, Masatsune Tsujioka, Michiko Murohashi, Shigeomi ShimizuAbstractAutophagy is a cellular process that degrades intracellular components, including misfolded proteins and damaged organelles. Many neurodegenerative diseases are considered to progress via the accumulation of misfolded proteins and damaged organelles; therefore, autophagy functions in regulating disease severity. There are at least two types of autophagy (canonical autophagy and al...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Purpose: Mesial temporal lobe epilepsy (MTLE) and Alzheimer's disease (AD) are two distinct neurological disorders associated with hippocampal atrophy. Our goal is to analyze the morphologic patterns of hippocampal atrophy to better understand the underlying pathological and clinical characteristics of the two conditions.Methods: Twenty-five patients with AD and 20 healthy controls with matched age and gender were recruited into the AD group. Twenty-three MTLE patients and 28 healthy controls with matched age and gender were recruited into the MTLE group. All subjects were scanned on 3T-MRI scanner. Automated volumetric an...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Molecules, Vol. 25, Pages 489: Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer’s Diseases Molecules doi: 10.3390/molecules25030489 Authors: Guo Yang Huang Tian Li Du Chen Liu Sun Liu A series of novel compounds 6a–h, 8i–1, 10s–v, and 16a–d were synthesized and evaluated, together with the known analogs 11a–f, for their inhibitory activities towards acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The inhibitory activities of AChE and BChE were ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
The decline of the vascular system with age takes numerous forms, such as a loss of capillary density, stiffening of blood vessel walls leading to raised blood pressure and increased rupturing of small vessels, and leakage of the blood-brain barrier that wraps blood vessels in the central nervous system. This vascular degeneration is a distinct process from the accumulation of metabolic waste, such as amyloid-β, that characterizes neurodegenerative diseases. Age-related conditions tend to have numerous distinct causes that interact over time to make one another worse, and this is certainly true of the aging of the bra...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
A new study from Temple University in Pennsylvania has found that boosting levels of a protein in mice genetically engineered to develop Alzheimer's cleared proteins that smother neurons.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
(Michigan Medicine - University of Michigan) New basic science and clinical research identifies TAU, the same protein studied in the development of Alzheimer's, as a biomarker for glioma development.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Abstract The catalytic potential of pyridine-2-carboxlic acid has been evaluated for efficient, green and solvent free synthesis of 2,4,5-trisubstituted imidazole derivatives. The compounds were synthesized by condensation reaction of substituted aromatic aldehydes, benzil and ammonium acetate ( 3a-3m ) in one pot in a good to excellent yield (74-96 %). These compounds were evaluated against acetylcholinesterase (AChE) enzyme activity to explore their potential against Alzheimer's disease. Among this series of compounds 3m bearing one ethoxy and a hydroxyl group on the phenyl ring on 2,4,5-trisubstituted imidazole...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research
TUESDAY, Jan. 21, 2020 -- No harms come from screening for Alzheimer disease and related dementias (ADRDs) in primary care, according to a study recently published in the Journal of the American Geriatrics Society. Nicole R. Fowler, Ph.D., from the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Authors: Baranowska-Wójcik E, Szwajgier D Abstract Introduction: Alzheimer's Disease (AD) is a progressive neurodegenerative pathology characterised by the presence of neuritic plaques and neurofibrillary tangles. The most important markers in AD pathology include excessive accumulation of amyloid beta (Aβ42) and phosphorylated tau (P-tau) proteins. One of the possible therapeutic strategies entails the elimination of such deposits by inhibiting Aβ aggregation. For years, one of the major problems in the treatment of AD has been the limited ability to deliver drugs to the brain for reasons related to ...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
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