The devil’s in the detail: cell-specific role of PPARγ in ILC2 activation by IL-33

Mucosal Immunology, Published online: 16 December 2020; doi:10.1038/s41385-020-00363-6PPARγ is a critical transcriptional regulator of adipogenesis and type 2 immune responses, however until recently its role in type 2 innate lymphoid cells had not been characterised. In two papers in this issue of Mucosal Immunology, PPARγ is shown to have a dominant role in ILC2 responses, mediating IL-33-responsiveness and activation.

Source: Mucosal Immunology - December 16, 2020 Category: Allergy & Immunology Authors: Henry J. McSorley J. Simon C. Arthur Source Type: research