Instant intra-operative neutropenia despite the emergence of banded (CD16dim/CD62Lbright) neutrophils in peripheral blood - an observational study during extensive trauma-surgery in pigs

Surgical intervention activates the innate immune system. A local immune response following tissue damage is mandatory to stimulate wound healing and to prevent infection. However, in the case of extensive surgery this immune reaction is not restricted to the surgical site, but rather stimulates a systemic inflammatory response syndrome (SIRS) [1,2]. Polymorphonuclear neutrophils (PMNs) are important effector cells in both local and systemic early responses to tissue damage. Neutrophils are equipped with several mechanisms to protect the host from harmful pathogens [3,4].

Source: Injury - November 6, 2020 Category: Orthopaedics Authors: Michel Teuben, Marjolein Heeres, Taco Blokhuis, Arne Hollman, Nienke Vrisekoop, Edward Tan, Roman Pfeifer, Hans-Christoph Pape, Leo Koenderman, Luke P.H. Leenen Source Type: research