Changes in gut microbial flora after Roux-en-Y gastric bypass and sleeve gastrectomy and their effects on post-operative weight loss

This study was designed to compare the effects of Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG) on two main phyla of the gut microbiota in humans and evaluate their potential effect on weight changes. Thirty morbidly obese patients were divided into two groups and underwent laparoscopic SG or laparoscopic RYGB. The patients ’ weight changes and fecal samples were evaluated at baseline and 6 months after the surgery. A microbial flora count was carried out of the phylaBacteroidetes andFirmicutes andBacteroides Fragilis. Changes in the abundance of the flora and their correlation with weight loss were analyzed. After 6  months, the patients with a history of RYGB showed a significant decrease in stoolBacteroidetes while the reduction in the SG group was insignificant.Firmicutes abundance was almost unchanged following SG and RYGB. There was no significant change inBacteroides Fragilis abundance in either of the two groups, but a positive correlation was observed betweenBacteroides Fragilis and weight loss after SG and RYGB. Bariatric surgery can affect gut microbiota. It can be concluded that these changes are dependent on many factors and may play a role in weight loss.
Source: Updates in Surgery - Category: Surgery Source Type: research