The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes.

The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes.
Biol Chem. 2020 Oct 01;:
Authors: Schult P, Paeschke K
Abstract
DHX36 is a member of the DExD/H box helicase family, which comprises a large number of proteins involved in various cellular functions. Recently, the function of DHX36 in the regulation of G-quadruplexes (G4s) was demonstrated. G4s are alternative nucleic acid structures, which influence many cellular pathways on a transcriptional and post-transcriptional level. In this review we provide an overview of the current knowledge about DHX36 structure, substrate specificity and mechanism of action based on the available models and crystal structures. Moreover, we outline its multiple functions in cellular homeostasis, immunity, and disease. Finally, we discuss the open questions and provide potential directions for future research.
PMID: 33021960 [PubMed - as supplied by publisher]

Source: Biological Chemistry - October 7, 2020 Category: Chemistry Tags: Biol Chem Source Type: research