Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis

Huang et  al. structurally and functionally analyzed ribosomal RNA-transcription-elongation complexes, showing how transcription factors and RNA elements are organized on RNA polymerase to suppress pausing and pre-mature termination and how the factors form a composite RNA chaperone that supports co-transcr iptional RNA folding and annealing of distal RNA regions.

Source: Molecular Cell - August 30, 2020 Category: Cytology Authors: Yong-Heng Huang, Tarek Hilal, Bernhard Loll, J örg Bürger, Thorsten Mielke, Christoph Böttcher, Nelly Said, Markus C. Wahl Tags: Article Source Type: research